Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

Development strategies for insoluble compounds require not only measurement of solubility enhancements achieved through formulation but also assessment of the effect a formulation has on permeability. An new dissolution-permeability measurement platform (µFLUX™) allows simultaneous monitoring of both effects thereby providing an in vitro path to early in vivo predictive biorelevant absorption testing.