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New and Exciting!
New research from the University of Kansas using Pion’s Scissor technology to test subcutaneous injections of Glatiramer Acetate, the active ingredient in Copaxone®, was published in the Journal of Controlled Release.
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Pion MacroFLUX – Realistic IVIVC Modeling
Introducing a stirred absorption chamber into the traditional USP I and II apparatus allows this type of testing to be done in vitro through the use of the MacroFLUX dissolution system. The USP vessel is the donor compartment, allowing for the volumes needed to test finished dosage forms under sink…
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Recommended Resources
| Image | Title | Product | Applications | Login To Download |
|---|---|---|---|---|
 | Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects | MacroFLUX, µFLUX™ | Flux across membranes, in Vitro, Permeability, Solubility | |
 | A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model | PAMPA Evolution™, PAMPA Explorer Frontier™ | in Vitro, Permeability | |
 | Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation | Scissor | In Vivo, Subcutaneous | |
 | Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products | MacroFLUX | Flux across membranes, in Vitro, In Vivo | |
 | Determination of pKa values and Solubility pH Profiles of Selected ß blockers | SiriusT3 | pKa | |
 | AN10 Measuring LogP of Samples that are Hard to Dissolve in Water and Octanol | SiriusT3 | Dissolution, log P | |
 | AN410 Measuring the isoelectric point pf peptides by potentiometric titration | SiriusT3 | Isoelectric, pKa, Subcutaneous | |
 | AN402 Controlled supersaturation assays for modelling intestinal precipitation | inForm | Dissolution, Precipitation, Solubility, Supersaturation | |
 | Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies | MacroFLUX | Absorption, Dissolution | |
 | Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds | µFLUX™ | Absorption, Dissolution, Flux across membranes, Permeability, Solubility | |
 | Studying semi-solid formulations of diclofenac using Skin PAMPA | Gut-Box™, PAMPA Evolution™, PAMPA Explorer Frontier™ | Flux across membranes, Permeability | |
 | Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes | AuPro™ Software, µDISS Profiler™, µFLUX™ | Amorphous state, Dissolution, Supersaturation |
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Most Popular Resources
| Image | Title | Product | Applications | Login To Download | Display Order |
|---|---|---|---|---|---|
 | pKa and physchem property measurements for the pharmaceutical industry | SiriusT3 | pKa | ||
 | WEBINAR: How pKa Values are used in the Pharmaceutical Industry | SiriusT3 | pKa | 1 | |
 | WEBINAR: In vitro measurement of drug bioavailability following subcutaneous injection | Scissor | Biotherapeutics, Subcutaneous | 7 | |
| Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects | MacroFLUX, µFLUX™ | Flux across membranes, in Vitro, Permeability, Solubility | 2 | |
 | Scissor subcutaneous poster | Scissor | Biotherapeutics, In Vivo, Subcutaneous | 5 | |
 | Subcutaneously administered biopharmaceuticals | Scissor | Biotherapeutics, Subcutaneous | 6 | |
 | MacroFLUX Generics | MacroFLUX | Flux across membranes, In Vivo | 5 | |
 | Measuring Physiochemical Properties 2 | SiriusT3 | log P, pKa, Solubility | 3 |
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