Blog - Pion

Blog

February 20, 2025

5 Benefits to Conducting Simultaneous Dissolution and Permeability Tests in Drug Development

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Flux experiments combine permeability testing with dissolution testing

Blog

February 18, 2025

Drug absorption and bioavailability

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Drug absorption and bioavailability in drug development

Blog

February 11, 2025

Pion’s BEE high pressure homogenizers (HPH) specialize in the liquid phase exfoliation of graphite to graphene

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BEE high pressure homogenizer exfoliate graphite to graphene

Blog

February 6, 2025

Testing Prodrugs In-vitro

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Get in depth understanding of your prodrug product and its behavior before reaching in vivo studies

Blog

February 4, 2025

Drug permeability and bioavailability

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What are drug permeability and bioavailability in drug development

Blog

January 30, 2025

Hits and Lead Optimization in drug development

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Drug development hit and lead optimization

Blog

January 28, 2025

What is a prodrug?

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Prodrugs highlight strategic design in drug development, overcoming biological barriers and enhancing therapeutic efficacy for effective treatment.

Blog

January 23, 2025

How the ionic strength affects the ionization constant (pKa)?

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Explore how ionic strength affects ion activity, pH, and drug properties like solubility and permeability. Learn why reporting pKa with media conditions matters

Blog

January 21, 2025

What is the Rainbow R6 Dynamic Dissolution Monitor?

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What is the Rainbow R6 UV vis spectrometer

Blog

January 13, 2025

Particle Drifting Effect in Drug Development

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Particle drift effect and how to predict or model GIT drug absorption rates

Blog

December 10, 2024

What is a UV-Vis Spectrophotometer?

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Discover how a UV-Vis spectrophotometer enhances pharmaceutical development and quality control

Blog

December 6, 2024

Dissolution and Flux Study for Bioequivalence Testing

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Dissolution and Flux Study for Generics Bioequivalence Testing using Rainbow Dynamic Dissolution Monitor with Flux apparatus Pion Inc.

Blog

December 5, 2024

Is the pKa of a drug affected by the biorelevant media?

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Is the pKa of a drug affected by the biorelevant media - drug development - physchem characterization

Blog

December 3, 2024

Streamlining Cannabis Formulations with Inline Pre-Processing (IPP)

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Inline Pre-Processing for cannabis formulations

Blog

December 3, 2024

Cell Lysis Protocol for Protein Isolation: Key Insights for Researchers

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Learn about the best cell lysis protocol for protein isolation, including physical and solution-based methods, from the experts at Pion.

Blog

November 18, 2024

What Are ALCOA+ Principles?

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What is ALCOA+ What are ALCOA+ principles

Blog

November 12, 2024

Advantages of small volume dissolution studies in drug development

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Small volume dissolution studies enable efficient, cost-effective drug development by conserving materials, reducing waste, and improving formulation insights.

Blog

November 5, 2024

7 Ways Homogenizers Are Used in Pharma Oral Dose Development

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7 Ways Homogenizers Are Used in Pharma Oral Dose Development

Blog

October 22, 2024

Drug solubility and permeability

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Drug solubility and permeability

Blog

October 17, 2024

What is blend uniformity?

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What is blend uniformity in oral solid dose?

Blog

October 15, 2024

Reversible protein complexes: Advancing subcutaneous delivery

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Reversible protein complexes: Advancing subcutaneous delivery

Blog

October 8, 2024

What is Lipophilicity?

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Learn about lipophilicity, a key factor in drug absorption, distribution, and efficacy. Discover its role in pharmacology with the Pion Sirius T3 instrument.

Blog

October 2, 2024

Derivative Spectroscopy

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Explore Derivative Spectroscopy, a powerful analytical method that improves absorbance spectra analysis by reducing interference from undissolved materials for accurate results

Blog

October 1, 2024

What are the 3 R's in Drug Testing

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What are the 3 Rs in Drug Testing

Blog

September 25, 2024

What is UV-Vis Spectroscopy?

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Learn how UV-Vis spectroscopy and the Rainbow R6 overcome challenges in kinetic solubility, dissolution, and precipitation experiments without filtration.

Blog

September 19, 2024

Hydrogel formats for subcutaneous injection simulation

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Hydrogel formats for subcutaneous injection simulation

Blog

September 17, 2024

The Role Of in vitro Testing In Drug Development

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The Role Of in vitro Testing In Drug Development

Blog

September 12, 2024

Common Equipment in a Drug Dissolution Testing Lab

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Common Equipment in a Drug Dissolution Testing Lab

Blog

September 10, 2024

Pion’s Predictor Software – A Formulator’s Tool to Understand Oral Drug Absorption Rate-Limiting Steps and Compound BCS Class

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Predictor software understanding rate-limiting steps in drug absorption

Blog

September 6, 2024

Nanoparticle Formulation: Advanced Approach using Pion’s BEE Brand High Pressure Homogenizers

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Pion BEE International homogenizers for nanoparticle formulation

Blog

September 3, 2024

Subcutaneous Delivery of High Concentration Biologics

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Subcutaneous Delivery of High Concentration Biologics

Blog

August 30, 2024

MacroFLUX to Study Final Dosage Forms

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MacroFLUX to Study Final Dosage Forms

Blog

August 14, 2024

SCISSOR subcutaneous injection site simulator for mAbs

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SCISSOR subcutaneous injection site simulator for mAbs

Blog

July 30, 2024

Biphasic dissolution and simultaneous dissolution-permeation apparatus

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Biphasic dissolution and simultaneous dissolution-permeation apparatus

Blog

July 25, 2024

Cell lysis and AAV gene therapy

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Cell lysis and AAV gene therapy

Blog

July 22, 2024

What are high-pressure homogenizers?

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What is a high pressure homogenizer

Blog

July 16, 2024

What is drug absorption?

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What is drug absorption in drug development

Blog

June 24, 2024

Developing poorly water-soluble drugs

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Poorly water-soluble drug development

Blog

June 18, 2024

Pion Predictor Software

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Pion Predictor Software for Drug Development

Blog

June 13, 2024

What are PROTACs?

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What are PROTACs Proteolysis targeting chimeras

Blog

May 30, 2024

Subcutaneous injection basics and formulation screening during drug development

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Drug development subcutaneous injection formulation screening

Blog

May 16, 2024

What is intrinsic dissolution rate?

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Intrinsic dissolution rate definition

Blog

May 2, 2024

Formulating with Less API: Exploring the Application of API Sparing Techniques in Oral Drug Development

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API Sparing Techniques in Oral Drug Development

Blog

April 24, 2024

What are solubility and supersaturation?

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Solubility and supersaturation

Blog

April 9, 2024

What is the difference between drug discovery, drug development and drug formulation?

drug development

Content Uniformity

Dissolution testing

Drug permeability

Injectables formulation

Drug discovery drug development and drug formulation

Blog

April 2, 2024

The Basics of Drug Flux and Permeability

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In vitro flux measurements predict in vivo drug permeability

Blog

March 26, 2024

Crossing the Blood Brain Barrier

PAMPA

oral drug development

Blood brain barrier

Pion PAMPA measures permeability of a compound across an artificial membrane that mimics the properties of the BBB

Blog

March 19, 2024

How Are Poorly Soluble Compounds Formulated into Drugs?

drug development

log P

oral solid dose

physchem characterization

pKa

How poorly soluble compounds are formulated into drugs

Blog

March 13, 2024

Speeding Sample Preparation and API Extraction from Solid Oral Dosage Formulations for QC Content Uniformity testing

Dissolution testing

oral solid dose

oral drug development

PrepEngine

PrepEngine speeds sample prep and API extraction from oral solid dose formulations

Blog

March 12, 2024

Particle Size Reduction 101: Homogenization, Dispersions & Emulsions

Dispersions

Emulsions

Homogenization

Particle Size Reduction

Particle size reduction is the process of reducing particle size using techniques, like homogenization, to create dispersions & emulsions.

Blog

March 11, 2024

In Vitro Surface Dissolution Imaging Assists in the Development of Intestine and Colon Delivered Drugs

Dissolution testing

drug development

oral drug development

Pion's SDI2 Surface Dissolution Imaging instrument for drug development

Blog

March 5, 2024

Rethinking Drug Formulation: The Motivation Behind Embracing Subcutaneous Delivery

drug development

Injectables formulation

Subcutaneous delivery

The re-formulation of drugs for subcutaneous delivery represents a transformative trend in the pharmaceutical industry

Blog

March 1, 2024

What is the Pion PrepEngine?

Cannabis

Cell Disruption

Dissolution testing

Content Uniformity

Pion PrepEngine multi-station lab blending instrument for content uniformity dissolution cannabis testing

Blog

February 27, 2024

What is Pion's MacroFLUX and How is it Related to Membrane Permeability?

Dissolution testing

drug development

oral drug development

oral solid dose

Drug permeability

MacroFLUX is a valuable asset for drug product optimization, batch-to-batch comparability and bioequivalence testing

Blog

February 27, 2024

How the Cell Wall Effects Homogenization

Cell Walls

Homogenization

Learn exactly how the cell wall effects homogenization so that you have all of the knowledge you need to be successful with your applications.

Blog

February 20, 2024

Exploring Protein Conformation and Stability in the Subcutaneous Space

drug development

Injectables formulation

The SCISSOR offers a unique opportunity for early screening of the in vivo performance of subcutaneously administered therapeutics in preclinical evaluation.

Blog

February 13, 2024

Why Do We Care About Protein Aggregation Post-Subcutaneous Injection?

Biotechnology

Pharmaceutical

By understanding the potential causes of aggregation and its consequences, researchers can minimize the risk of immune responses and inflammation

Blog

February 9, 2024

Real-time In situ/In vitro Dissolution Measurements in Drug Development and Their Connection to Particle Size: The link between homogenization/micronization and dissolution

Dissolution testing

drug development

In situ Dissolution Measurements and Biorelevant Solubility and Dissolution of Poorly Soluble Drugs

Blog

February 6, 2024

The Advantages of BEE brand homogenizers for cell lysis

Cell Disruption

Cell Lysis

drug development

High Pressure Homogenization

Pion's BEE brand homogenizers for cell lysis

Blog

January 30, 2024

Parallel artificial membrane permeability assay (PAMPA) and its role in drug development

drug development

oral solid dose

Pharmaceutical

PAMPA

Parallel artificial membrane permeability assay (PAMPA) and its role in drug development

Blog

January 25, 2024

Advantages of fiber-optic probe-based UV spectrometers

Dissolution testing

Fiber optic UV spectrometers in dissolution testing offer improved sensitivity, real-time monitoring, and compatibility with different dissolution methods.

Blog

January 22, 2024

Self-unfolding foils in drug delivery

drug development

oral drug development

Self-unfolding foils in drug delivery release monitoring

Blog

January 19, 2024

Pion's Role In Drug Development

Dissolution testing

drug development

Injectables formulation

log P

pKa

Pion Inc. in Drug development

Blog

January 16, 2024

Introduction to log P and log D measurement using PionT3

drug development

oral drug development

oral solid dose

physchem characterization

log P

What is log P in drug development

Blog

January 10, 2024

What is in vitro dissolution testing?

Dispersions

oral drug development

oral solid dose

Dissolution testing

In vitro dissolution testing is a method used in pharmaceutical development and quality control to evaluate the release rate of an active ingredient or drug.

Blog

January 5, 2024

What are ADME and IVIVC in drug development?

drug development

physchem characterization

pKa

oral drug development

Pharmaceutical

ADME and in vitro in vivo correlation

Blog

January 4, 2024

6 reasons why you should upgrade to the Scissor N3 subcutaneous injection site simulator

Biotechnology

Injectables formulation

Pharmaceutical

drug development

Scissor N3: In vitro model simulating subcutaneous injection for biopharmaceutical formulation ranking and excipient screening.

Blog

January 2, 2024

New Tool for Simulating Subcutaneous Injection

drug development

Injectables formulation

Learn about the impact of injection.

Blog

December 28, 2023

Food effect risk assessment in preformulation stage using material sparing microFLUX methodology from Pion

drug development

oral drug development

oral solid dose

flux

Pion microFLUX used to assess food effect in preformulation stage

Blog

December 26, 2023

UV Fiber Optic Solution for QC Dissolution Testing

drug development

oral drug development

QC Dissolution

Rainbow Fiber Optic UV-vis Solution for QC Dissolution Testing

Blog

December 23, 2023

Flux-Based Formulation Development in ADDF

drug development

oral drug development

oral solid dose

ADDF

Flux-Based Formulation Development in Absorption Driven Drug Formulation (ADDF)

Blog

December 22, 2023

What is the Absorption Driven Drug Formulation (ADDF) concept?

drug development

ADDF

Absorption Driven Drug Formulation (ADDF) in drug development

Blog

December 21, 2023

Understanding the effect of digestion on oral, lipid-based drug formulations using Rainbow and MicroDISS

drug development

oral drug development

oral solid dose

Pharmaceutical

How Pion's Rainbow and MicroDISS are used for lipid based oral drug formulation

Blog

December 20, 2023

The Pion Sirius T3 Physchem Instrument

physchem characterization

drug development

pKa

oral solid dose

Pharmaceutical

The SiriusT3 physchem platform from Pion is an advanced analytical instrument used for measuring physicochemical properties

Blog

December 18, 2023

Passive membrane permeability, drug flux, and oral absorption

drug development

oral drug development

oral solid dose

Passive membrane permeability, drug flux, and oral absorption in oral drug development

Blog

December 13, 2023

What is pKa and how is it used in drug development?

pKa

physchem characterization

drug development

In drug development, the knowledge of pKa is important as it influences the solubility, oral absorption, distribution, and pharmacokinetics of a drug.

Blog

December 12, 2023

What are BCS Class II drugs?

Pharmaceutical

BCS Class II drugs, also known as highly permeable and poorly soluble drugs, are drugs that have low aqueous solubility but high membrane permeability.

Blog

December 12, 2023

What is Nano CBD and how is it made?

Cannabis

Dispersions

Emulsions

Food and Beverage Processing

High Pressure Homogenization

Nano CBD refers to cannabidiol (CBD) that has been broken down into nanoparticles. Nanoparticles are tiny particles that range in size from 1 to 100 nanometers.

Blog

March 9, 2023

Strategies to Reduce Drug Discovery and Development Time

High Pressure Homogenization

Pharmaceutical

Homogenization

Bee High-Pressure Homogenizers can be used to reduce drug discovery and development time.

Blog

March 9, 2023

Managing Chemically Aggressive and Abrasive Products with High Pressure Homogenizers

Chemical

High Pressure Homogenization

Homogenization

Learn how to manage chemically aggressive and abrasive products with high pressure homogenizers.

Blog

March 9, 2023

The Importance of Nanoemulsions for Drug Discovery

High Pressure Homogenization

Nanoemulsification

Homogenization

Pharmaceutical

Nanoemulsions are important for drug discovery and high pressure homogenizers from Bee International are great tools for creation.

Blog

August 17, 2022

Cannabis Processing: Sonication vs. High Pressure Homogenization

High Pressure Homogenization

Particle Size Reduction

Cannabis

Homogenization

Here, we'll explore the reasons why high pressure homogenization is more effective for cannabis processing than sonication.

Blog

August 1, 2022

Graphene Processing: When Particle Size Reduction Isn’t Enough

High Pressure Homogenization

Particle Size Reduction

Graphene

In today's blog, we discuss why high-pressure homogenizers like the ones at BEE International are the key to improving graphene processing.

Blog

May 27, 2022

Why Cell Disruption is More Efficient Using Homogenization

High Pressure Homogenization

Particle Size Reduction

Cell Disruption

Homogenization

There are several tools that can help facilitate cell lysis, but homogenization is the only cell disruption method that fits a wide range of applications.

Blog

March 25, 2022

3 Materials Where Particle Size is Essential for Effective Production

High Pressure Homogenization

Particle Size Reduction

Homogenization

Cannabis

Food and Beverage Processing

Particle size and distribution are important aspects in the manufacturing of many products including food, pharmaceuticals, and cannabis products.

Blog

February 28, 2022

How Better Particle Packing Improves Pharmaceutical Suspensions

High Pressure Homogenization

Particle Size Reduction

Pharmaceutical

Pharmaceutical suspensions are a crucial part of accurate dosage delivery. High-pressure homogenization ensures the most consistent particle distribution.

Blog

January 27, 2022

What Is Cavitation and How Does it Compare to Shear Mixing Forces?

High Pressure Homogenization

Cavitation

Many types of forces can be employed in the process of homogenization. But what is cavitation? How does it compare to other forces? We'll explore here.

Blog

December 28, 2021

3 Industries Where Ultrasonic Emulsification is Changing the Game

Emulsions

High Pressure Homogenization

Homogenization

Ultrasonic emulsification is relied on by many industries to deliver quality products to customers. High-pressure homogenization is a better alternative.

Blog

November 29, 2021

The Role of Nanoemulsification Equipment in Cannabis Beverage Processing

Cannabis

Food and Beverage Processing

Homogenization

Nanoemulsification

In today's blog, we'll break down how nanoemulsion equipment is vital to the production of cannabis beverages to ensure stability and consistency.

Blog

October 28, 2021

The Ultimate Guide to Particle Size Reduction Equipment

Homogenization

Particle Size Reduction

Learn how to choose the best particle size reduction equipment for your next project here where we break down the many ways to reduce particle size.

Blog

September 29, 2021

How to Guarantee Water Soluble Cannabinoids for Beverages

Cannabis

Food and Beverage Processing

Homogenization

In this blog, explore the importance of homogenizers in creating water soluble cannabinoids for beverages, a process that challenges many manufacturers.

Blog

August 27, 2021

How Cavitation is Used in Chemical Engineering

Homogenization

Cavitation

Chemical

Chemical engineers rely on cavitation to homogenize particles within colloidal suspensions, thus enabling them to create a wide range of chemical products.

Blog

August 13, 2021

An Introduction to Creating Colloidal Solutions

Homogenization

Colloidal Solutions

High Pressure Homogenization

Creating colloidal solutions is a critical process that affords us many useful and vital products for everyday life. Here’s what you need to know!

Blog

July 16, 2021

High Pressure Homogenizers for Nanomilling for Bioavailability Enhancement

Food and Beverage Processing

Homogenization

Larn more about what makes BEE International high pressure homogenizers the superior choice when nanomilling for bioavailability enhancement

Blog

May 28, 2021

What’s the Best Way to Lyse Bacterial Cells?

High Pressure Homogenization

Cell Walls

Biotechnology

Homogenization

Pharmaceutical

What’s the best way to lyse bacterial cells, essentially killing them and rendering them incapable of causing illness and disease? Read to find out.

Blog

November 23, 2020

What is Microfluidization and How Does It Work?

Particle Size Reduction

Get all the information you need about microfluidization and how it works. This could be the solution that you've been looking for, so learn more now!