Small volume dissolution testing in drug development offers several benefits, primarily related to efficiency, cost-effectiveness, and improved data quality. This type of testing is greatly enhanced when combined with simultaneous permeability testing.
Here are some key advantages to small volume dissolution testing:
Reduced Sample Volume: Small volume testing requires significantly less drug product and dissolution medium, allowing for the low-concentration evaluation of highly potent compounds or valuable formulations only available in limited quantities.
Cost-Effectiveness: By minimizing the amount of drug and materials consumed, small volume testing can lower the overall costs of testing, which is particularly beneficial during early phases of drug development.
Increased Throughput: Smaller test volumes enable the use of higher throughput screening techniques, allowing for the rapid assessment of multiple formulations or conditions simultaneously. This accelerates the development timeline.
Reduction of Waste: With smaller sample volumes, the amount of waste generated from solvents and other dissolution media is minimized, contributing to more sustainable laboratory practices.
Improved Sensitivity and Detection: Small volume tests often utilize advanced detection methods, allowing for greater sensitivity in measuring dissolution rates and improving the reliability of results.
Enhanced Predictive Ability: Small volume dissolution testing can provide valuable early insights into the behavior of formulations in biological systems, assisting in the prediction of in vivo performance from in vitro data.
In summary, small volume dissolution testing is a valuable tool in drug development, enabling more efficient use of resources, facilitating early-stage formulation evaluation and optimization.
Pion offers several different small volume dissolution testing platforms to meet your needs. Many of these additionally offer the ability to conduct permeability (flux) measurements at the same time as the dissolution test. An in situ UV vis fiber optic probe is placed directly in the dissolution bath and optional flux chamber for real-time results, which further reduces solvent usage involved in traditional offline sampling analysis. Combining dissolution testing with permeability testing can vastly improve in vitro-in vivo correlation (IVIVC) of drug entities.
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