In vitro flux measurements, also known as permeability assays, involve measuring the rate at which a drug molecule moves across a simulated biological membrane. These measurements can provide valuable information about a drug's ability to permeate through various barriers in the body, such as the intestinal wall or the blood-brain barrier.
By comparing in vitro flux measurements to in vivo data, researchers can predict how well a drug will be absorbed and distributed in the body. For example, if a drug has a high permeability rate in an in vitro assay, it is likely to be well absorbed and have good bioavailability in vivo. On the other hand, if a drug has low permeability in vitro, it may have poor absorption and lower therapeutic effectiveness in the body.
In vitro flux measurements are an important tool in the drug development process for predicting drug permeability and optimizing drug delivery strategies. Pion offers several different flux formats to accommodate various sample sizes, from MicroFLUX to biorelevant MacroFLUX.
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