Paper summary and review: Hydrogel Formats to Model Potential Drug Interactions Occurring at the Subcutaneous Injection Site
Conor Gomes, Kate Gridley, Imogen Anastasiou, Bálint Sinkó, Randall J. Mrsny
"We have previously developed an in vitro instrument, termed Subcutaneous Injection Site Simulator (SCISSOR), that can be used to monitor release properties of an active pharmaceutical ingredient (API) and formulation components of a medicine designed for SC injection.
...We now report a type of cross-linked HA that can, when combined with HA, provide a hydrogel (HA-XR) with optical clarity and rheological properties that remain stable for at least 6 days.
...Together, these data have demonstrated the feasibility of using a cross-linked HA format to examine API release over multiple days and incorporation of specific ECM elements to prepare more biomimetic hydrogels that allow for tractable examination of their potential impact of API release."
Watch the video where Conor Gomes discusses this paper.
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