Oral Formulation Delivery
Get richer insights earlier for oral formulation development: optimize formulations to be administered orally & absorbed through the stomach, intestine, or GI tract.
Pharmaceutical formulation development is the critical stage of transforming a new drug substance into a powerful and commercially-viable drug product.
Oral formulation is the development of drug products designed for delivery by mouth. Drugs administered in this way are absorbed by the stomach, intestine, or gastrointestinal tract and are often formulated into tablets or capsules.
Scientists are focused on identifying the best method for achieving effective drug performance and delivery for the patient.
Formulation development scientists require fast and reliable tools that enable them to better predict how an oral formulation will perform in the body prior to human studies (in vitro-in vivo correlation: IVIVC).
Pion’s solutions give scientists this power.
Optimal dose selection identifies the formulation that best balances the benefit of the drug with risk
Characterization of physicochemical properties is one of the key challenges to develop a pharmaceutical active ingredient into a drug.
Dissolution
The measure of a drug dissolving
Ionization
The measure of dissociation into ions which occurs when an electrolyte is dissolved
Absorption
The measure of absorption of the formulation
Solubility
The measure of the maximum concentration of a solute that can dissolve in a solvent at a given temperature
Permeability and Flux
The measure of the ability to cross membranes
Lipophilicity
The measure of the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents
Pion’s instruments provide a range of PK/PD measurements:
- Solubility
The measure of the maximum concentration of a solute that can dissolve in a solvent at a given temperature
- Permeability and Flux
The measure of the ability to cross membranes
- Lipophilicity
The measure of the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents
Oral Formulation Delivery
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