Pilot & Industrial Homogenizers
Reproduce the same product quality as developed in your laboratory
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PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Reproduce the same product quality as developed in your laboratory
Process pressures up to 45,000 PSI
Patented Emulsifying Cell (EC) that allows individual control over the 3 separate homogenization forces: Shear, Cavitation and Impact
A linear process which enables us to guarantee the scalability of results
World-class support and customer service for maximum up time, including service level agreements, preventative maintenance, and genuine OEM replacement parts
Unique flexibility to meet every customer’s particular requirements
Our Advanced Homogenizing Technology
The heart of our homogenizing technology is our patented EC, (Emulsifying Cell). Designed with many options the EC is a powerful tool for product developers. There are a finite number of mechanical forces used by any process equipment to mix, blend, and grind products:
- Shear – like HIGH SHEAR mixers. STIRRERS and AGITATORS
- Cavitation like SONIC mixers
- Impact – like BEAD MILLS
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Emulsifying Cell
Unlike the above mixers, which focus on one mechanical force, the BEE Emulsifying Cell allows the product developer to combine and control a combination of these forces to optimize new and improved products. Pion technology supplies each of these mechanical forces with greater maximum intensity.
Our equipment produces higher shear rates than high shear mixers and in-line cavitation which is economically scalable unlike batch sonic mixers. Learn more about our High-Pressure Intensifier System to see how this is accomplished.
The EC is a modular device that can be easily setup in a wide variety of configurations to achieve different process effects.
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