DeBEE 2000
The DeBEE 2000 combines R&D level versatility with pilot scale production capabilities
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
The DeBEE 2000 combines R&D level versatility with pilot scale production capabilities
One versatile instrument capable of advanced process customization as well as increased production capacity
Uaranteed scalability
Take a proven product with established processing protocols and replicate results to accommodate business growth and development
The Ultimate Development Tool, Suitable for Production High Pressure Homogenizer
- cGMP, CE, CFR 21 Part 11
- Electronic signatures
- User management
- Audit trail
- Data collection
- SCADA
- Plant integration ready
- Clean in Place
The DeBEE 2000 series includes the following models:
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Applications
- Micro and nanoemulsions and
- dispersions
- Effective cell disruption
- Tighter distribution of uniform
- particle size reduction
- Efficient nano-encapsulation
- Small and uniform liposomes
- De-agglomeration
- Extended product stability
- Improve Bioavailability
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DeBEE 2000
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