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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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This paper showcases data illustrating the viability of employing a cross-linked HA format to study API release over extended periods. It also explores the integration of specific ECM elements to create biomimetic hydrogels for a thorough investigation of their influence on API release.
Publication
A hydrogel format of HA + Col I was used to examine the complex events for bevacizumab release under conditions where a target ligand (vascular endothelial growth factor) can interact with extracellular matrix (ECM). Together, these data have demonstrated the feasibility of using a cross-linked HA format to examine API release over multiple days and incorporation of specific ECM elements to prepare more biomimetic hydrogels that allow for tractable examination of their potential impact of API release.