Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate

Purpose. A newly developed device was applied to assess the feasibility of performing in situ UV concentration monitoring experiments in 96-well microtitre plate format.

Conclusion.  The study confirmed the feasibility of performing in situ dissolution and solubility monitoring in 96-well plate that was not possible before. In addition to high throughput solubility determination, other critical studies such as salt dissolution screening, dissolution/solubility determination in biorelevant media, solubility-excipient screening and others can be performed much earlier in the drug discovery saving costs by dramatically reducing required amount of compounds and expensive reagents.