Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF

For certain drugs, notably BCS Class 2, an over-reliance on dissolution testing, in isolation, can be sub-optimal to efficient progress. The ADDF concept pioneered by Pion focuses on flux, and the use of assays that simultaneously measure dissolution and permeability to assess the net impact of formulation changes. Flux measurements allow formulators to identify the excipients and formulation strategies that are most likely to deliver the bioavailability and drug delivery performance required, rather than simply dissolution and solubility equivalence.