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Subcutaneous Injection Site Simulator Assay

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Subcutaneous Injection Site Simulator Assay

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Pion Analytical Services offers the ability to compare, de-risk, and design your subcutaneous drug candidates in vitro using the SCISSOR technique.

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Dissolve Macro Orange

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Subcutaneous Injection Site Simulator Assay

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At Pion, we offer a custom-made service using our SCISSOR technique coupled with our unparalleled expertise, tailoring the experiments to your individual application, from mAbs to small molecules, simple solutions to complex in-situ forming gels – we’re here to help.

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Dissolve Macro Orange
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Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing
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DissoPro Software v3.6
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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Subcutaneous Injection Site Simulator Assay
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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
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Pion's BEE Brand Homogenizers - The Ultimate Research Tool
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Introduction to Pion's BEE brand high-pressure homogenizers
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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Using NaOH and NaCl instead of KOH and KCl
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Solubility and Supersaturation - A Brief Introduction
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Scissor N3 overview and demo
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Scissor as a platform for the analysis of non-protein subcutaneous formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Considerations on the Controlled Release of Injectable Insulin Using Scissor
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Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
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Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions
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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
Poster
Penetration Enhancer Effect of Sucrose Esters
Poster
Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
Poster
Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
Poster
Drug Permeation in Skin PAMPA and Franz Cell Model
Poster
In Situ Solubility and Dissolution of Concentrated Solutions
Poster
Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
Poster
Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
Poster
Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
Poster
Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
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Nanoparticle Formulation of Gresiofulvin
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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C
Poster
Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials
Poster
Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
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Evaluation of Optimized Caco-2 Permeability Measurements
Poster
Developing Skin PAMPA for Transdermal Patches
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Supersaturation and Transmembrane Flux of Meloxicam
Poster
Universal Potentiometric Sensors Food Matrixes
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Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
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Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies
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Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration
Poster
Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
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Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
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In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
Poster
Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
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Dissolution and Precipitation Monitoring of Crystalline Salts
Poster
Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method
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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
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Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
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Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
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