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Micro DeBEE

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Micro DeBEE

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Benefit from high yield, extended stability, enhanced bioavailability, and precise particle size distribution to achieve top yield results.

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Dissolve Macro Orange

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Micro DeBEE

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Learn about Pion's Micro DeBEE homogenizer, an innovation in process equipment, the air operated Micro DeBEE homogenizer combines a variety of mixing tools into one advanced instrument.  With unique process setups you can select the intensity and force of mixing parameters:

  • Cavitation
  • Pressure
  • Shear
  • Back Pressure
  • Impact
  • Process Duration

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Dissolve Macro Orange
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Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing
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Micro DeBEE
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Introduction to Pion's BEE brand high-pressure homogenizers
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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Using NaOH and NaCl instead of KOH and KCl
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Measurement of Extreme pKas
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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Dissolution Testing
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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
Poster
Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques
Poster
Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
Poster
MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
Poster
Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
Poster
Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions
Poster
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
Poster
Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
Poster
Penetration Enhancer Effect of Sucrose Esters
Poster
Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
Poster
Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
Poster
Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
Poster
Drug Permeation in Skin PAMPA and Franz Cell Model
Poster
In Situ Solubility and Dissolution of Concentrated Solutions
Poster
Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
Poster
Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
Poster
Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
Poster
Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
Poster
Nanoparticle Formulation of Gresiofulvin
Poster
Universal Potentiometric Sensors Protein Binding
Poster
In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C
Poster
Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials
Poster
Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
Poster
Evaluation of Optimized Caco-2 Permeability Measurements
Poster
Developing Skin PAMPA for Transdermal Patches
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Supersaturation and Transmembrane Flux of Meloxicam
Poster
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Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
Poster
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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
Poster
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Poster
In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
Poster
Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
Poster
Dissolution and Precipitation Monitoring of Crystalline Salts
Poster
Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method
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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
Poster
Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
Poster
Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
Poster
Novel HT Method for Parallel Excipient/Vehicle Formulation Studies
Poster
Using Skin PAMPA For Transdermal Patch Testing
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