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Predictive power and operational use of SCISSOR to streamline SC biologics drug development

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Predictive power and operational use of SCISSOR to streamline SC biologics drug development

Webinar

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Discover the secrets to predicting bioavailability of SC biologics with Merck and Pion in this informative OnDemand webinar!

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Dissolve Macro Orange

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Predictive power and operational use of SCISSOR to streamline SC biologics drug development

Webinar

Understanding and predicting bioavailability of subcutaneously (SC) administered biologics remains a key challenge in drug development. There is a need for reliable predictive models to improve formulation development and dose estimation for SC biologics.

View this OnDemand webinar where Merck and Pion explore the effectiveness and practical application of the Subcutaneous Injection Site Simulator (SCISSOR, Pion Inc.) - a promising in vitro model that aims to streamline the development of SC biologics.

Webinar

Dissolve Macro Orange
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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Predictor Software
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Service agreement plans
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SiriusT3 Lite - A PhysChem Platform
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Predictive power and operational use of SCISSOR to streamline SC biologics drug development
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The impact of colloids and nanoparticles on intestinal drug absorption
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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site
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Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
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Pion's BEE Brand Homogenizers - The Ultimate Research Tool
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Introduction to Pion's BEE brand high-pressure homogenizers
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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Using NaOH and NaCl instead of KOH and KCl
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The Determination of Solubility - Pion CheqSol Explained
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Solubility and Supersaturation - A Brief Introduction
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Scissor N3 overview and demo
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Scissor as a platform for the analysis of non-protein subcutaneous formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Considerations on the Controlled Release of Injectable Insulin Using Scissor
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Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules
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How to Achieve Efficient & Consistent Particle Size Reduction e-book
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Homogenization For Cannabis e-book
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Advantages of BEE Homogenizers for the Pharmaceutical Industry e-book
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Reversal of IDO-mediated cancer immune suppression
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Control of Oral Bioavailability by Particle Sizes
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Method for preparing propofol emulsion for vascular injection
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Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
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Nanoparticle Formation
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DeBEE 4000
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Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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Nano DeBEE
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PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root
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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques
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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
Poster
MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
Poster
Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
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Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions
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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
Poster
Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
Poster
Penetration Enhancer Effect of Sucrose Esters
Poster
Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
Poster
Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
Poster
Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
Poster
Drug Permeation in Skin PAMPA and Franz Cell Model
Poster
In Situ Solubility and Dissolution of Concentrated Solutions
Poster
Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
Poster
Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
Poster
Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
Poster
Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
Poster
Nanoparticle Formulation of Gresiofulvin
Poster
Universal Potentiometric Sensors Protein Binding
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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C
Poster
Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials
Poster
Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
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Evaluation of Optimized Caco-2 Permeability Measurements
Poster
Developing Skin PAMPA for Transdermal Patches
Poster
Supersaturation and Transmembrane Flux of Meloxicam
Poster
Universal Potentiometric Sensors Food Matrixes
Poster
Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
Poster
Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies
Poster
Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration
Poster
Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
Poster
Skin-PAMPA: Fast Prediction of Skin Penetration
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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
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Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
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In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
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Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
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Dissolution and Precipitation Monitoring of Crystalline Salts
Poster
Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method
Poster
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
Poster
Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
Poster
Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
Poster
Novel HT Method for Parallel Excipient/Vehicle Formulation Studies
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Using Skin PAMPA For Transdermal Patch Testing
Poster
In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles
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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes
Poster
Progress in pKa Determination Technology: Case Studies in Low and High Soluble Flavonoids
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Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds
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Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
Poster
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster
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