Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

The timeframe of supersaturation and potential precipitation events may have profound effects on bioavailability. The aim of this study was to develop a practical, easily standardized and predictive in vitro dissolution method to monitor powder/formulation dissolution and concomitant precipitation processes in biorelevant media dynamically being changed from simulated gastric to simulated intestinal fluid. The importance of such API-sparing, two-stage, in vitro microdissolution tests to study drug-drug interaction in the case of pH-modifying agents was reported recently.