Skin-PAMPA: Fast Prediction of Skin Penetration

Purpose.  Transdermal delivery has facilitated the development of new drugs during the last few decades.  This work evaluated the interlaboratory performance of Skin PAMPA measurements conducted at Pion and by a well-known pharmaceutical supplier.

Conclusions.  As previously reported, Skin PAMPA measurements was highly correlated against Franz cell measurements (human epidermis) using fifteen different APIs.  The Skin PAMPA measurements of seven test compounds as performed in two different labs was in good agreement.  And lastly, both Skin PAMPA and the Franz cell method could easily distinguish between the API permeability in four different formulations.  These observations continue to demonstrate the potential utility of this new technique for rapid screening in a cost effective manner.