Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen

Purpose. This work studied the applicability of a recently introduced skin-mimetic artificial membrane permeability model (Skin PAMPA) to differentiate between topical pharmaceutical formulations. The Skin PAMPA results were compared with data obtained from in vitro Franz cell permeability measurements.Conclusion. The new formulation is demonstrated to be superior in delivering ibuprofen through a skin barrier compared with the commercial benchmark. The Skin PAMPA model can be used with topical formulations to differentiate their ability for transdermal delivery of active pharmaceutical ingredients. Standardization potential and the high-throughput nature of Skin PAMPA can be a valuable cost effective compliment to Franz cell permeability experiments for early skin penetration prediction and topical formulation development.