Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

Purpose. The objective was to investigate the feasibility of using a miniaturized disk intrinsic dissolution rate (IDR) apparatus to determine the Biopharmaceutics Classification System (BCS) solubility class while significantly reducing compound consumption comparing to traditional Wood’s apparatus. Additional goal was to develop an approach where IDR measurements performed in media of different buffer capacity could be compared.

Conclusion. The results demonstrate that using 100-fold less drug does not sacrifice the quality of the measurement, and lends support to an earlier study1 that the disk IDR measurement may possibly serve as a surrogate for the BCS solubility classification. API-sparing miniaturized IDR measurements can be done much earlier in the drug development cycle.