Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials

Purpose.  The objective of the study was to predict human jejunal permeability, Peff, and absorption, %Fa, for a series of fluoroquinolones, using a biophysical model based on measured Caco-2 permeability.  Values of Peff have not been reported for these compounds, and not all of the compounds have reported human absorption values.

Conclusion.  Estimates of Peff can be predicted by the biophysical model. From these values, the human absorption may be calculated.  Where absorption comparisons were possible, the agreement was acceptably good.