Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder

Purpose. The objective of the study was to develop the method of in situ concentration monitoring of free API being released from its nanosuspension without the need for separation of un-dissolved nanoparticles. The comparison of dissolution behavior of micronized and untreated naproxen (API) powder with kinetics of free API release from nano- and microsuspensions was also the goal of this work.

Conclusion. Developed method allowed in situ measurement of free API concentration in solution in the presence of nanoparticles. Solubility of naproxen was the same within several standard deviations between all forms of naproxen studied. However dissolution from nanoparticles was practically instantaneous compared to the case of microsuspension or powders.