Validation of the SDi2 intrinsic dissolution rate measurement

Here we present a validation study whereby IDR measurements using the SDi2 are compared with published values from using the USP rotating disk method. The SDi2 is a unique small-scale flow-through instrument for biorelevant IDR measurement of compacts, employing real-time UV/Vis imaging to create a video of the dissolution process directly at the solid-dissolution medium interface.