Using SDi2 to characterise swelling and drug release profiles
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Applications Note
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Applications Note
The SDi2 surface dissolution imaging system provides unique insights into physical phenomena that occur at the interface of a drug product and dissolution medium. These phenomena are by necessity overlooked using compendial dissolution techniques, because concentration measurements are usually taken downstream of the dissolution process, yet they are key to understanding the full picture of how a formulation will perform in vivo. The SDi2 is used to observe and measure such effects of erosion, swelling, disintegration and drug release from API compacts or formulated whole dosages in a single experiment, enabling rapid, informed decisions to be made during dosage form selection/optimization.