Study of Danazol Cocrystal using Trans-membrane Flux Measurements

Pharmaceutical cocrystals have emerged as one of the potential strategies to enable supersaturation for poorly soluble drugs and as a result to improve their oral absorption and bioavailability . Flux across a membrane provides a better understanding of passive absorption of solutes from supersaturated solutions, since solute activity rather than concentration is the driving force. This study was aimed at investigating how supersaturation of model drug danazol released from its cocrystal in biorelevant media affects the trans-membrane flux of this low soluble compound.