In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation

The rapid dissolution rate of many water-soluble, immediate release solid dosage forms requires a dissolution analyzer that is fast, sensitive, customizable for frequent measurements, and able to generate data of high precision and quality. These requirements fit perfectly with today’s in situ fiber optic technology. The Rainbow Dynamic Dissolution Monitor was used in this study to demonstrate and evaluate the dissolution behavior of 500 mg Vitamin B12 (cyanocobalamin) tablets in degassed water, simulated gastric fluid (SGF), and phosphate buffer.