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Extended Instrument Shut Down for Pion SDi2 Storage Guidelines

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Extended Instrument Shut Down for Pion SDi2 Storage Guidelines

Applications Note

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Extended Instrument Shut Down for Pion SDi2 Storage Guidelines

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Applications Note

To safely store the SDi2, the following should be removed from the instrument, emptied, cleaned/flushed, and stored dry:

• Fluidics lines*

• Reagent and waste bottles

• Flow cells

• All accessories.

Applications Note

Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing

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DissoPro Software v3.6

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Webinar: LIVE DEMO! Taking in vitro Data to in vivo Prediction

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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Subcutaneous Injection Site Simulator Assay

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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Predictor Software

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Service agreement plans

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SiriusT3 Lite - A PhysChem Platform

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Predictive power and operational use of SCISSOR to streamline SC biologics drug development

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The impact of colloids and nanoparticles on intestinal drug absorption

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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study

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Micro DeBEE

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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis

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Pion's BEE Brand Homogenizers - The Ultimate Research Tool

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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX

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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF

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Introduction to Pion's BEE brand high-pressure homogenizers

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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements

Applications Note

Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules

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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy

Applications Note

Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

Applications Note

Using NaOH and NaCl instead of KOH and KCl

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Introduction to log P and log D measurement using PionT3

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Measuring log P of samples that are hard to dissolve in water and octanol

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The Determination of Solubility - Pion CheqSol Explained

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The use of cosolvent pKa assays for poorly soluble compounds

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Measurement of Extreme pKas

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Solubility and Supersaturation - A Brief Introduction

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Scissor N3 overview and demo

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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations

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Scissor as a platform for the analysis of non-protein subcutaneous formulations

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Understanding excipient effect in vitro using the Pion Scissor

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Considerations on the Controlled Release of Injectable Insulin Using Scissor

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Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules

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How to Achieve Efficient & Consistent Particle Size Reduction e-book

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Homogenization For Cannabis e-book

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Advantages of BEE Homogenizers for the Pharmaceutical Industry e-book

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7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book

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Reversal of IDO-mediated cancer immune suppression

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Control of Oral Bioavailability by Particle Sizes

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Method for preparing propofol emulsion for vascular injection

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Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment

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Nanoparticle Formation

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DeBEE 4000

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Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools

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Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.

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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride

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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System

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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus

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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids

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Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions

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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing

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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus

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Penetration Enhancer Effect of Sucrose Esters

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Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set

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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

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Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies

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Drug Permeation in Skin PAMPA and Franz Cell Model

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In Situ Solubility and Dissolution of Concentrated Solutions

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Powder Intrinsic Dissolution Rate Measurement: When is it Possible?

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Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model

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Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds

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Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores

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Nanoparticle Formulation of Gresiofulvin

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Universal Potentiometric Sensors Protein Binding

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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C

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Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials

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Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate

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Evaluation of Optimized Caco-2 Permeability Measurements

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Developing Skin PAMPA for Transdermal Patches

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Supersaturation and Transmembrane Flux of Meloxicam

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Universal Potentiometric Sensors Food Matrixes

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Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder

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Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies

Poster

Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration

Poster

Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds

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Skin-PAMPA: Fast Prediction of Skin Penetration

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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder

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Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions

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In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds

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Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen

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Dissolution and Precipitation Monitoring of Crystalline Salts

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Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method

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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media

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Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

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Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

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Novel HT Method for Parallel Excipient/Vehicle Formulation Studies

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Using Skin PAMPA For Transdermal Patch Testing

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In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles