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Extended Instrument Shut Down for Pion SDi2 Storage Guidelines

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Extended Instrument Shut Down for Pion SDi2 Storage Guidelines

Application Notes

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Extended Instrument Shut Down for Pion SDi2 Storage Guidelines

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Application Notes

To safely store the SDi2, the following should be removed from the instrument, emptied, cleaned/flushed, and stored dry:

• Fluidics lines*

• Reagent and waste bottles

• Flow cells

• All accessories.

Application Notes

4 Benefits to Conducting Simultaneous Dissolution and Permeability Experiments in Drug Development

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Carbon Nanotube Application Test Data and Results

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Conserving biorelevant enzymatic activity during in vitro subcutaneous drug testing

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DissoPro Software v3.6

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Webinar: LIVE DEMO! Taking in vitro Data to in vivo Prediction

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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Subcutaneous Injection Site Simulator Assay

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Advancements in hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Service agreement plans

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SiriusT3 Lite - A PhysChem Platform

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Predictive power and operational use of SCISSOR to streamline SC biologics drug development

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The impact of colloids and nanoparticles on intestinal drug absorption

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Hydrogel formats to model potential drug interactions occurring at the subcutaneous injection site

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Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus - An aripiprazole case study

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Micro DeBEE

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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis

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Pion's BEE Brand Homogenizers - The Ultimate Research Tool

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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX

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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF

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Introduction to Pion's BEE brand high-pressure homogenizers

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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements

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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules

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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy

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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics

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Using NaOH and NaCl instead of KOH and KCl

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Introduction to log P and log D measurement using PionT3

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Measuring log P of samples that are hard to dissolve in water and octanol

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The Determination of Solubility - Pion CheqSol Explained

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The use of cosolvent pKa assays for poorly soluble compounds

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Measurement of Extreme pKas

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Solubility and Supersaturation - A Brief Introduction

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Scissor N3 overview and demo

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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations

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Scissor as a platform for the analysis of non-protein subcutaneous formulations

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Understanding excipient effect in vitro using the Pion Scissor

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Considerations on the Controlled Release of Injectable Insulin Using Scissor

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Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules

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How to Achieve Efficient & Consistent Particle Size Reduction e-book

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Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.

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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride

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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus

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Penetration Enhancer Effect of Sucrose Esters

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Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set

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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

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Drug Permeation in Skin PAMPA and Franz Cell Model

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In Situ Solubility and Dissolution of Concentrated Solutions

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Powder Intrinsic Dissolution Rate Measurement: When is it Possible?

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Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model

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Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds

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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C

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Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds

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