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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

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µDISS Profiler, µFLUX apparatus and AuPRO software supersaturation of amorphous forms

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Dissolve Macro Orange

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

Poster

Case studies demonstrating capability of µDISS Profiler, µFLUX apparatus and AuPRO software to determine the degree and extent of supersaturation of amorphous forms and differentiate them from liquid-liquid phase separation.

Poster

Dissolve Macro Orange
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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Using NaOH and NaCl instead of KOH and KCl
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The Determination of Solubility - Pion CheqSol Explained
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Considerations on the Controlled Release of Injectable Insulin Using Scissor
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root
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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques
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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
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Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions
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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
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Penetration Enhancer Effect of Sucrose Esters
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Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
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Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
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Drug Permeation in Skin PAMPA and Franz Cell Model
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In Situ Solubility and Dissolution of Concentrated Solutions
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Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
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Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
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Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
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Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
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Nanoparticle Formulation of Gresiofulvin
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Supersaturation and Transmembrane Flux of Meloxicam
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Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
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Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
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Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
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Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
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In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles
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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes
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