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Enabling SEDDS Formulation Choice through In Vitro-In Vivo Correlation with BASF and Pion

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Enabling SEDDS Formulation Choice through In Vitro-In Vivo Correlation with BASF and Pion

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Absorption rate of the Active Pharmaceutical Ingredient (API) can be enhanced by fine tuning the composition of SEDDS.

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Dissolve Macro Orange

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Enabling SEDDS Formulation Choice through In Vitro-In Vivo Correlation with BASF and Pion

Webinar

In this webinar, you can learn the steps BASF took, in partnership with Pion, in developing enhanced SEDDS formulations based on their surfactant emulsion properties, including droplet size and hydrophilicity. BASF generated in vitro information via Pion technology, and as a result, were able to report enhanced IVIVC performance for SEDDS formulations.

Webinar

Dissolve Macro Orange
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Micro DeBEE
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Demonstrating the excipient effect in vitro for subcutaneous pre-clinical formulation analysis
Whitepaper
Pion's BEE Brand Homogenizers - The Ultimate Research Tool
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
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Exploring the value of flux measurements in drug formulation and development: Bioavailability beyond dissolution rate alone. ADDF
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Introduction to Pion's BEE brand high-pressure homogenizers
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Predicting the Relative In Vivo performance of Nanoformed and Crystalline Bulk Piroxicam Solid Suspensions from In Vitro Flux Measurements
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Revisiting 2nd derivative UV spectroscopy for real-time monitoring of structural changes and complexations of macromolecules
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Real time monitoring the extent of plasmid-liposome complexation using 2nd derivative fiber-optic UV spectroscopy
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Using NaOH and NaCl instead of KOH and KCl
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The Determination of Solubility - Pion CheqSol Explained
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Solubility and Supersaturation - A Brief Introduction
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Scissor N3 overview and demo
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Scissor as a platform for the analysis of non-protein subcutaneous formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Considerations on the Controlled Release of Injectable Insulin Using Scissor
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Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules
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Advantages of BEE Homogenizers for the Pharmaceutical Industry e-book
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7 Key Factors to Consider When Choosing A Cell Lysis Method - e-book
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Reversal of IDO-mediated cancer immune suppression
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Control of Oral Bioavailability by Particle Sizes
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Method for preparing propofol emulsion for vascular injection
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Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
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Nanoparticle Formation
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DeBEE 4000
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Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools
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Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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MiniDeBEE
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Nano DeBEE
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DeBEE 2000
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Dissolution Testing
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PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root
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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques
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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
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Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions
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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
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Penetration Enhancer Effect of Sucrose Esters
Poster
Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
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Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
Poster
Drug Permeation in Skin PAMPA and Franz Cell Model
Poster
In Situ Solubility and Dissolution of Concentrated Solutions
Poster
Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
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Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
Poster
Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
Poster
Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
Poster
Nanoparticle Formulation of Gresiofulvin
Poster
Universal Potentiometric Sensors Protein Binding
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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C
Poster
Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials
Poster
Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
Poster
Evaluation of Optimized Caco-2 Permeability Measurements
Poster
Developing Skin PAMPA for Transdermal Patches
Poster
Supersaturation and Transmembrane Flux of Meloxicam
Poster
Universal Potentiometric Sensors Food Matrixes
Poster
Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
Poster
Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies
Poster
Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration
Poster
Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
Poster
Skin-PAMPA: Fast Prediction of Skin Penetration
Poster
Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
Poster
Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
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In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
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Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
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Dissolution and Precipitation Monitoring of Crystalline Salts
Poster
Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method
Poster
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
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Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
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Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
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Novel HT Method for Parallel Excipient/Vehicle Formulation Studies
Poster
Using Skin PAMPA For Transdermal Patch Testing
Poster
In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles
Poster
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes
Poster
Progress in pKa Determination Technology: Case Studies in Low and High Soluble Flavonoids
Poster
Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds
Poster
Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
Poster
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster
Poster
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools
Poster
Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes
Poster
Utilization of pH-Metric Titration
Poster
Application of Skin Pampa to Cosmetic Solvent Screening
Poster
Karl Box Sunrise Presentation
Poster
Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies
Poster
Supersaturation in additives and GI fluids
Poster
Determination of Polymer Effectiveness
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