The library of scientific research contains a high proportion of dubious findings, much of which resulted from poor experimentation. In support of this, the biotech firm Amgen recently found that only 6 of 53 major cancer research findings could be replicated; how poorly this statistic reflects on an industry that is so heavily based in fact
Researchers striving for high quality and reproducible results should use equipment that will work exactly as programmed, and which will achieve better results than its competitors. Pion Inc. manufactures BEE brand homogenizers that contain a proprietary Emulsifying Cell, which holds numerous benefits for processes that involve cell lysis and/or particle size reduction.
1. Design replicates passing through the cell multiple times
The reactors in the Emulsifying Cell induce absorption, which creates a new blend of products and/or extends the process duration. Thus, as particles exit the Emulsifying Cell, they are further reduced over again. One pass through the BEE homogenizer thus has the effect of multiple passes, with the cost and time efficiency of only one or two passes. The number of passes a product must make for complete and uniform particle size reduction is a common measure of homogenizer quality; it is rare for a homogenizer to achieve quality results in just 1-2 passes. As such, the BEE Emulsifying Cell should be the go-to equipment for any homogenizer needs.
2. Flexibility to alter the process
The Emulsifying Cell contains multiple locations that contribute to particle size reduction, and which can be adjusted based on the specific process and cells being used. One of the system’s central benefits is this flexibility, which allows scientists across industries to optimize their particle size reduction processes. For example, the force of cavitation is imparted once a product exits the nozzle, and contributes to the breaking of cell walls. More or less cavitation can be employed for gentler or harsher cell disruption by simply turning a dial to vary operating pressure. Similarly, the force of impact further breaks cells apart, but is only needed for samples that contain strong cell walls. When running a sample with weak walls, or lacking cell walls, a different setup can be programmed to avoid the impact step altogether.
3. High shear compared to other high shear mixers
Shear tears particles apart, which causes a reduction in size. Significantly higher compared with other high shear mixers, shear levels in the Emulsifying Cell are impacted by both velocity and length. As described above, the user has control over the amount of shear imparted on a sample, so that optimal results can be achieved.
Pion Inc: The BEE Brand Homogenizer Advantage
On determining which homogenizer will be right for your lab, begin your search with Pion. We are globally recognized among laboratory managers and researchers for our high-quality products and excellent customer support. Cell lysis and particle size reduction are two of a variety of applications for BEE homogenizers; nano/micro emulsions, lipids, suspensions, and dispersions are also easily achievable. Additionally, the homogenizer processes can be controlled to suit your product, which will allow you to customize to your cell type. And finally, the equipment is easy to use, produces higher yield in less time, and achieves results that are reproducible and scalable.
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