BioFLUX™

Advancing In Vitro Tools for Subcutaneous Formulation

Gut Box for PAMPA

Webinar On Demand: Cannabis Flower and CBD based Sample Preparation Techniques

Impact of Gastric pH Variations on the Release of Amorphous Solid Dispersion Formulations Containing a Weakly Basic Drug and Enteric Polymers

Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz

Acidity constants of hydroxyl groups placed in several flavonoids: Two flavanones, two flavones and five flavonols

LabEye | A ready-to-implement multi-camera system performing visual process monitoring

Pion PrepEngine | Single or multi-station content uniformity blending platform.

VIDEO: Membrane Flux in-vitro : BioFLUX, MacroFLUX, MicroFLUX

Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five”

Methodological Considerations in Development of UV Imaging for Characterization of Intra-Tumoral Injectables Using cAMP as a Model Substance

Unveiling Solubility, Dissolution and Permeability In Vitro: How GSK Sees the (UV) Light

Preparation and advanced characterization of highly drug-loaded, 3D printed orodispersible tablets containing fluconazole

Virtual Cocrystal Screening of Adefovir Dipivoxyl: Identification of New Solid Forms with Improved Dissolution and Permeation Profiles

Enabling SEDDS Formulation Choice through In Vitro-In Vivo Correlation with BASF and Pion

Advanced in vitro methods in generic drug product development

"Exciting new development for our SCISSOR - ECM XR artificial extracellular matrix for extended-release studies"

Release notes - DissoPro 3.6 software for the Rainbow UV in-situ concentration monitor

Parallel Artificial Membrane Permeability Assay (PAMPA) Platform - Product Sheet

Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media

Best Practices for PhysChem determination using Pion SiriusT3

Best practices in Fiber Optic Dissolution Testing

SCISSOR N3 Product Sheet

Scissor Demo

MacroFLUX Demo

microDISS Profiler Demo

AuPRO 7.0

Rainbow R6 Product Sheet

Introducing *NEW* Rainbow R6!

"The Absorption Driven Drug Formulation Concept" Webinar

"Utilizing Pion's SiriusT3 Platform" Webinar

Analytical Services Brochure

"Small Scale in vitro Techniques as Predictive Tools for in vivo Performance" Webinar

"Simulating Biologic Post Injection Events Utilizing the Pion Scissor" Webinar

"miniDISS Profiler Including the *NEW* miniDT" Webinar

"SDi2: Unlocking the Secrets of Your Dissolution" Webinar

"Pion MacroFLUX for Predictive Dissolution Absorption Measurements" Webinar

"Pion's Analytical Services" Webinar

"Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar

Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices

Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number

Considerations on the Controlled Release of Injectable Insulin Using Scissor (Subcutaneous Injection Site Simulator)

miniDISS Profiler Video

Pion 1-page Product Overview

miniDISS Profiler Brochure

MicroDISS Profiler - an introduction

SiriusT3 Product Brochure

Extended Instrument Shut Down for Sirius T3 Storage Guidelines

Extended Instrument Shut Down for Pion Rainbow Storage Guidelines

Extended Instrument Shut Down for Pion PULSE Storage Guidelines

Extended Instrument Shut Down for Pion SDi2 Storage Guidelines

Dissolution Template 61

Extended Instrument Shut Down for Pion Scissor Storage Guidelines

Introducing DissoPRO Version 3.5 – a powerful GMP ready fiber optic software solution

Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution

Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

Diclofenac Prodrugs for Intra-articular Depot Injectables: In Vitro Hydrolysis and Species Variation

A video introduction into microDISS Profiler™ instrument and its applications

Probing the mechanism of bupivacaine drug release from multivesicular liposomes

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives

Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

From Traditional Dissolution to In Vivo Predictive Flux Measurements

Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds

Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift

Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations

Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms

Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states

Comparison of Cinchona Catalysts Containing Ethyl or Vinyl or Ethynyl Group at Their Quinuclidine Ring

pKa and physchem property measurements for the pharmaceutical industry

WEBINAR: How pKa Values are used in the Pharmaceutical Industry

WEBINAR: Understanding and Measuring pKa

Webinar: AuPRO™ Version 6.0: New Powerful Tools for Pion’s Fiber Optic Users

AuPRO Comparison Flyer

Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions

Development of a novel method utilising dissolution imaging for the measurement of swelling behaviour in hydrophilic matrices

Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. I. Description of a two-phase in vitro dissolution test

Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test

Toward Biorelevant Dissolution: Application of a Biphasic Dissolution Model as a Discriminating Tool for HPMC Matrices Containing a Model BCS Class II Drug

Overcoming sink limitations in dissolution testing:a review of traditional methods and the potential utility of biphasic systems

Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus

In vivo predictive mini-scale dissolution for weak bases: Advantages of pH-shift in combination with an absorptive compartment

Evaluation of a biphasic in vitro dissolution test for estimating the bioavailability of carbamazepine polymorphic forms

Development of a discriminative biphasic in vitro dissolution test and correlation with in vivo pharmacokinetic studies for differently formulated racecadotril granules

Development of a biphasic dissolution test for Deferasirox dispersible tablets and its application in establishing an in vitro-in vivo correlation

In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review

Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts

Developing Quantitative In Vitro-In Vivo Correlation for Fenofibrate Immediate-Release Formulations With the Biphasic Dissolution-Partition Test Method

Discriminatory Potential Of Biphasic Medium Over Compendial And Biorelevant Medium For Assessment Of Dissolution Behavior Of Tablets Containing Meloxicam Nanoparticles

Selection of a discriminant and biorelevant in vitro dissolution test for the development of fenofibrate self-emulsifying lipid-based formulations

Dissolution of poorly water-soluble drugs in biphasic media using USP 4 and fiber optic system

Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics

Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: Polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs

Insight into the Development of Dissolution Media for BCS Class II Drugs: A Review from Quality Control and Prediction of In Vivo Performance Perspectives

Application of a Biphasic Test for Characterization of In Vitro Drug Release of Immediate Release Formulations of Celecoxib and Its Relevance to In Vivo Absorption

Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. II. Improved in vitro-in vivo correlation using a two-phase dissolution test

Biorelevant test for supersaturable formulation

A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model

Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation

Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions

UV imaging in pharmaceutical analysis

Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging

Application of UV Imaging in Formulation Development

Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination

LogP as a tool in intramolecular hydrogen bond considerations

Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

Simultaneous UV Imaging and Raman Spectroscopy for the Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes

Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method

Dissolution rate of ciprofloxacin and its cocrystal with resorcinol

Acid‐base titrations of proteins in small volumes

The impact of cosolvent on measured log P values

Determination of hydrogen bonding properties using logP

Detection of poor acid resistance of enteric coats using the SDI

AAPS Advanced imaging, detection and prediction of initial gel formation and swelling of hypromellose compacts

Understanding the self-assembly process of industrially relevant co-crystals

Studying Crystallisation & Dissolution Processes Using Particle Size & Shape Analysis

AAPS2017 T5029 Particle Sizing

High-throughput phospholipidosis screening

Surface tension and supersaturation

Approaches for measuring intestinal precipitation rates of oral drugs

Approaches for measuring intestinal precipitation rates

Measuring the isoelectric point of peptides by potentiometric titration

Investigating the driving force of membrane transport of carvedilol from supersaturated solutions achieved by ...

MacroFLUX DDI

Solubility Measurement

Measuring Physiochemical Properties

PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement

WEBINAR: Measuring solubility - what’s best for you?

WEBINAR: Physicochemical Properties and their relation to ADMET

WEBINAR: How Cheqsol Works

WEBINAR: Investigating Supersaturation and Solubility Enhancement

The behaviour of drug formulations under biorelevant and biphasic conditions

WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs

WEBINAR: State of the art UV methods for measuring pKa

WEBINAR: Accessing hydrogen bond parameters and their application in drug discovery

WEBINAR: Log P- History, Measurement and Applications in Drug Development

WEBINAR: In vitro measurement of drug bioavailability following subcutaneous injection

In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

Kinetics of drug release from ointments: Role of transient-boundary layer

Novel oral formulation approach for poorly water-soluble drug using lipocalin-type prostaglandin D synthase

Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process

Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro-in vivo evaluations

Crystal Structure and Physicochemical Characterization of Ambazone Monohydrate, Anhydrous, and Acetate Salt Solvate

Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs

Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

Miniaturized rotating disk intrinsic dissolution rate measurement: effects of buffer capacity in comparisons to traditional Wood’s apparatus

Miniaturized Intrinsic Dissolution Rate (Mini-IDR™) Measurement of Griseofulvin and Carbamazepine

Dissolution and Solubility (in Comprehensive Medicinal Chemistry II, Vol. 5)

In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation

Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Dissolution Media

Spectrophotometric pKa determination of ionizable pharmaceuticals: Resolution of molecules with weak pH-dependent spectral shift

Drug ionization and physicochemical profiling

pH-metric solubility. 3. Dissolution titration template method for solubility determination

pH-Metric Solubility. 2. Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods

Structure-lipophilicity relationships of neutral and protonated b-blockers, part I: intra and intermolecular effects in isotropic solvent systems

Octanol-, Chloroform-, and PGDP-Water Partitioning of Morphine-6-Glucuronide and Other Related Opiates

pH-Metric logP. 4. Comparison of Partition Coefficients Determined by HPLC and Potentiometric Methods to Literature Values

Determination of Protonation Macro- and Microconstants and Octanol/Water Partition Coefficient of Antiinflammatory Niflumic Acid

A Versatile Potentiometric Analyzer, Part Two: Multiple Known Addition and Gran Titration Techniques

A Versatile Potentiometric Analyzer, Part One: Hardware, the User Interface, and Titration Techniques

Weighting Scheme for Regression Analysis Using pH Data from Acid-Base Titrations

Bjerrum Plots for the Determination of Systematic Concentration Errors in Titration Data

Accurate Measurements of the Concentration of Hydrogen Ions with a Glass Electrode: Calibrations Using the Prideaux and Other Universal Buffer Solutions and a Computer-Controlled Automatic Titrator

Ketoconazole Salt and Co-crystals with Enhanced Aqueous Solubility

Solubility-Excipient Classification Gradient Maps

Solubility of sparingly-soluble drugs

A measured solution

Factors influencing the water solubility of crystalline drugs. (in Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability)

in vitro dissolution-absorption evaluation of an electrospun cyclodextrin-based formulation of aripiprazole using µFLUX

Investigation of the Efficacy of Transdermal Penetration Enhancers Through the Use of Human Skin and a Skin Mimic Artificial Membrane

P-Glycoprotein Deficient Mouse in situ Blood-Brain Barrier Permeability and its Prediction using an in combo PAMPA Model

The permeation of amphoteric drugs through artificial membranes - an in combo absorption model based on paracellular and transmembrane permeability

Coexistence of passive and active carrier-mediated uptake processes in drug transport: a more balanced view

Study on permeability enhancing effect of new ceramide-analogues by PAMPA method

How well can the Caco-2/MDCK models predict effective human jejunal permeability?

Absorption-Excipient-pH Classification Gradient Maps: Sparingly-Soluble Drugs and the pH Partition Hypothesis

Membrane-water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel

Permeation of permanently charged molecules through artificial membranes - influence of physicochemical properties

PAMPA—critical factors for better predictions of absorption

PAMPA - a Drug Absorption in vitro Model. 13. Chemical Selectivity due to Membrane Hydrogen Bonding: in combo Comparisons of HDM-, DOPC-, and DS-PAMPA

HT solubility and permeability: MAD-PAMPA analysis. (in Pharmacokinetic Profiling in Drug Reasearch: Biological, Physicochemical, and Computational Strategies)

PAMPA-Excipient Classification Gradient Maps

Caco-2 Permeability of Weakly Basic Drugs Predicted with the Double-Sink PAMPA pKa flux Method

Advances in Screening for Membrane Permeability: High-Resolution PAMPA for Medicinal Chemists

Assessing the Impact of Polymers on the pH-Induced Precipitation Behavior of Poorly Water-Soluble Compounds using Synchrotron Wide Angle X-Ray Scattering

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

Novel N-methylsulfonamide and Retro-N-methylsulfonamide Derivatives as 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors with Good ADME-Related Physicochemical Parameters

Physico-chemical Profiling of the ACE-inhibitor Lisinopril: Acidbase Properties

Solubility-pH Profiles of some Acidic, Basic and Amphoteric Drugs

Partial Protection Against Multiple RT-SHIV162P3 Vaginal Challenge of Rhesus Macaques by a Silicone Elastomer Vaginal Ring Releasing the NNRTI MC1220

pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties

Acidity and Hydrophobicity of Several New Potential Antitubercular Drugs: Isoniazid and Benzimidazole Derivatives

Physicochemical investigation of the influence of saccharide-based parenteral formulation excipients on l-p-boronphenylalanine solubilisation for boron neutron capture therapy

Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists

The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions

Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship. Anal Chim Acta 2010, 673 (1), 40-46. * Comer, J., Supersaturation effects in drug development

Structural and thermodynamic analyses of alpha-L-fucosidase inhibitors

New ideas about the solubility of drugs

The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides

Using measured pKa, LogP and solubility to investigate supersaturation and predict BCS class

The chemistry of multi-protic drugs Part 1: A potentiometric, multi-wavelength UV and NMR pH titrimetric study of the micro-speciation of SKI-606

The Rise of PAMPA

PAMPA - a drug absorption in vitro model. 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones

Absorption using the PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)

PAMPA - a Drug Absorption in vitro Model. 8. Apparent Filter Porosity and the Unstirred Water Layer

Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine

PAMPA - a Drug Absorption in vitro Model. 11. Matching the in vivo Unstirred Water Layer Thickness by Individual-Well Stirring in Microtitre Plates

Acid-Base Cosolvent Method for Determining Aqueous Permeability of Amiodarone, Itraconazole, Tamoxifen, Terfenadine and Other Very Insoluble Molecules

In vitro permeability of poorly aqueous soluble compounds using different solubilizers in the PAMPA assay with liquid chromatography/mass spectrometry detection

PAMPA - a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa flux - optimized design (pOD-PAMPA)

In vitro trans-monolayer permeability calculations: often forgotten assumption

The effect of formulation additives on in vitro dissolution-absorption profile and in vivo bioavailability of telmisartan from brand and generic formulations

Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions

Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling

Fast Simultaneous Determination of logP and pKa by Potentiometry: para- Alkoxyphenol Series (Methoxy to Pentoxy)

Cadmium binding by biological ligands. Part 4. Polynuclear complexes of cadmium with 2,3-dimercaptopropane-1-sulphonic acid

pH‐Metric log P. Part 1. Difference Plots for Determining Ion‐Pair Octanol‐Water Partition Coefficients of Multiprotic Substances

pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances

pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances.

Measurement of pKa and logP of Water-Insoluble Substances by Potentiometric Titration

pH-metric logP. 6. Effects of Sodium, Potassium and N-CH3-D-Glucamine on the Octanol-Water Partioning of Prostaglandins E1 and E2

Influence of two fatty amine surfactants on foliar absorption, translocation and efficacy of 2,4-D triethanolamine salt

Fungicidal activity of N-(2-cyano-2-methoxiaminoacetyl) amino acids and their derivatives

The prediction of the lipophilicity of peptidomimetics. A comparison between experimental and theoretical lipophilicty values of renin inhibitors and their building blocks

Validation of pH-Metric Technique for Measurement of pKa and logPow of Ionizable Herbicides

Limits for Successful Measurement of pKa and logP by pH-Metric Titration

Interlaboratory study of logP determination by shake-flask and potentiometric methods

Assessment of distribution- pH profiles

Ionization and Partitioning Profiles of Zwitterions: The Case of the Anti-Inflammatory Drug Azapropazone

1-octanol/water partition coefficient (Kow) amd pKa for ionizable pesticides measured by a pH-metric method

Practical aspects of partition measurements according to GLP rules

Lipophilicity profiles of ampholytes

Lercanidipine: short plasma half-life, long duration of action and high cholesterol tolerance. Updated molecular model to rationalize its pharmacokinetic properties

5-(piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1, 4-benzodiazepines: High-affinity, basic ligands for the cholecystokinin-B receptor

Quantitative structure-activities among macrolide antibacterial agents: in vitro and in vivo potency against Pasturella Multicoda

Lipophilicity behaviour of model and medicinal compounds containing a sulfide, sulfoxide, or sulfone moiety

pH electrode performance under automated management conditions

Potentiometric pKa determination of water-insoluble compounds. Validation study in methanol/water mixtures

pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs

Mechanisms of liposomes/water partitioning pf (p-methylbenzyl) alkylamines

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

Considerations on the potentiometric logP determination

Multiwavelength spectrophotometric determination of acid dissociation constants of ionisable drugs

pH-metric logP 11. pKa determination of water-insoluble drugs in organic solvent- water mixtures

Multiwavelength spectrophotometric determination of acid dissociation constants. Part IV. Water-insoluble pyridine derivatives

Multiwavelength spectrophotometric determination of acid dissociation constants Part III. Resolution of multi-protic ionization systems

Multiwavelength spectrophotometric determination of acid dissociation constants: Part II. First derivative vs. target factor analysis

Determination of liposome partitioning of ionizable drugs by titration

N-substituted analogues of S-nitroso-N-acetypenicillamine: chemical stability and prolonged nitric oxide mediated vasodilation in isolated rat femoral arteries

Drug liposome partitioning as a tool for the prediction of Human passive intestinal absorption

Ionization constants and distribution coefficients of phenothiazines and calcium channel antagonists determined by a pH-metric method and correlation with calculated partition coefficients

BUFMAKE: a computer program to calculate the compositions of buffers of defined buffer capacity and ionic strength for ultra-violet spectrophotometry

Structure-lipophilicity relationships of neutral and protonated-blockers, part I: intra and intermolecular effects in isotropic solvent systems

Multiwavelength spectrophotometric determination of acid dissociation constants Part VI. Deconvolution of binary mixtures of ionizable compounds

Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as a model compound

Multiwavelength spectrophotometric determination of acid dissociation constants Part V. Tautomerization microcontstants

Physicochemical characterization of sildenafil: Ionization, lipophilicity behaviour, and ionic-partition diagram studied by two-phase titration and electrochemistry

Rapid Physicochemical Profiling as an Aid to Drug Candidate Selection

Solubility challenge: can you predict solubilities of 32 molecules using a database of 100 reliable measurements?

Multiwavelength Spectrophotometric Resolution of the Micro- equilibria of a Triprotic Amphoteric Drug: Methacycline

Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants: A Validation Study

Concomitant hydrate polymorphism in the precipitation of sparfloxacin from aqueous solution.

Multiwavelength Spectrophotometric Resolution of the Micro-Equilibria of Cetirizine

A new method for the reproducible generation of polymorphs: two forms of sulindac with very different solubilities.

Lipophilicity behaviour of the zwitterionic antihistamine cetirizine in phospatidylcholine liposomes/water systems

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors

High throughput physicochemical profiling for drug discovery

Lipophilicity Profiles: Theory and Measurement

Diclofenac Solubility: Independent Determination of the Intrinsic Solubility of Three Crystal Forms

Physicochemical Properties of a New Multicomponent Cosolvent System for the pKa Determination of Poorly Soluble Pharmaceutical Compounds.

Potentiometric and spectrophotometric pKa determination of water-insoluble compounds: Validation study in a new cosolvent system. Anal. Chim

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

Presentation of a Structurally Diverse and Commercially Available Drug Data Set for Correlation and Benchmarking Studies

Calculation of Abraham Descriptors from solvent-water partition coefficients in four different systems; evaluation of different methods of calculation

A new multi-wavelength spectrophotometric method for the determination of the molar absorption coefficients of ionisable drugs

Application of hydrogen bonding calculations in property based drug design

Equilibrium vs. kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution - a validation study

New findings on the synthesis of the centrally acting muscle relaxant chlormezanone and its resolution of a gram scale using a Chiralcel OD column

Hydantoin-Substituted 4,6-Dichloroindole-2- carboxylic Acids as Ligands with High Affinity for the Glycine Binding Site of the NMDA Receptor

Ionization Constants and Ionization profiles

Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties

A potentially simpler approach to measure aqueous pKa of insoluble basic drugs containing amino groups

Physical and molecular properties of agrochemicals: an analysis of screen inputs, hits, leads and products

Ionization, Lipophilicity and solubility properties of repaglinide

Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases.

High Throughput Measurement of pKa values in a mixed-buffer linear pH gradient system

High Throughput measurement of drug pKa values for ADME screening

A modification of the Hammett equation for predicting ionization constants of p-vinyl phenols.

High throughput measurement of logD and pKa In Drug Bioavailability. Estimation of Solubility, Permeability and Bioavailability

Permeability through DOPC/dodecane membranes: measurement and LFER modelling

Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products

Direct imaging of the dissolution of salt forms of a carboxylic acid drug

Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation

A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model

Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects

Scissor subcutaneous poster

Subcutaneously administered biopharmaceuticals

MacroFLUX Generics

Measuring Physiochemical Properties 2

4‐case chart to classify supersaturation and precipitation behavior

Measuring pKa values in 2-propanol to gain process understanding

Ionization Constants of Isoniazid and Benzimidazole

pH-metric titration to characterize aci-nitro tautomerism

Effects of solubility enhancing excipients

A DoE study to understand partition rate in a biphasic system

Evaluation of in vitro tests to reduce animal testing in drug toxicology studies

Faster Dissolution Methods

Low Volume Dissolution Assays

The effect of dissolution media, torque and flow speed

Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation

Supersaturation time with CheqSol using different excipients AZ

Supersaturation, phase separation and measurement of precipitation rates

AAPS 2017 Supersaturation excipients poster KBox

AAPS 2017 Supersaturation modelling poster KBox

Biorelevant dissolution - the quest for simple in-vitro experiments

AAPS Understanding drug release mechanisms of metformin using complementary in vitro dissolution tools

AAPS 2017 Flo-Vitro poster KBox

A pH stat method to measure the dissolution rate of nano- and microparticle suspensions

Visualising the release patterns of promethazine across microparticulate systems

Biphasic dissolution studies of Felodipine

Dissolution & precipitation studies of carbamazepine cocrystals with small scale assays

Dissolution of a drug in the presence of additives and biorelevant media

Dissolution in presence of lipid to mimic absorption

Dissolution Experiments in Lipid Layers

Small scale assays for studying dissolution of cocrystals

Small volume dissolution of a poorly soluble drug as solid dispersions

In-situ pH change on a biphasic dissolution model in the presence of SIFs

Use of SDI to assess dissolution characteristics - John Comer (Pion)

Application of the SDI in Pharmaceuticals - Mei Wong (Pfizer)

Dissolution Imaging Symposium 2013 - Book of Abstracts

Solubility of drugs in the presence of excipients in lipid based formulations

Supersaturation & precipitation of ionizable drugs with cellulose polymers

Physicochemical Studies of Triclosan

Simulated Lung Fluid media

Solubility measurement by extrapolation

Solubilities of morphine analogs

Biphasic dissolution studies: Impact of concentration and particle size on partition rate

Improvements in biphasic dissolution

Biphasic dissolution studies of Aripiprazole

Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution

Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution

Characteristics of Felodipine ‐ HPMCAS Solid Dispersions

Dissolution Performance of Inhaled Products in Simulated Lung Fluid

In-situ Solubility Measurements of Ionizable Drugs

Determination of Aqueous Solubility by Extrapolation

A low volume method for screening Plasdone® polymers

Assay Expert Flyer

SDi Digest

Biphasic Dissolution Case Study of Carvedilol

Salts Dissolution

A pH stat method to measure the dissolution rate of nano- and microparticle suspensions

Biphasic Dissolution Studies

BCS Class IV formulation: case study

Triclosan: a PhysChem study

AN405 Controlled supersaturation by solvent-quench

AN404 Biorelevant dissolution with gradient pH adjustment

AN403 GI lipolysis of lipid based drug formulations

AN402 Controlled supersaturation assays for modelling intestinal precipitation

AN401 Biphasic Dissolution

Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt

AN410 Measuring the isoelectric point pf peptides by potentiometric titration

AN15 Determination of pKa Measurement or Prediction?

AN14 Using NaOH and NaCL instead of KOM and KCI

AN13 Measuring Solubility What’s Best for You?

AN12 Introduction to logP and logD Measurement Using SiriusT3

AN11 Evaluating Solid Dispersion using Small-Scale Dissolution Testing

AN10 Measuring LogP of Samples that are Hard to Dissolve in Water and Octanol

AN09 The Determination of Solubility - Pion CheqSol Explained

AN08 Solubility and Supersaturation - A Brief Introduction

AN07 the Pion GI Dissolution Assay

AN06 The use of cosolvent pKa assays for poorly soluble compounds

AN05 Measurement of extreme pKas

AN04 Insights into BCS classification using Pion assays

AN03 Blank Titrations Using the SiriusT3

AN02 PKa measurements in 15 minutes - the SiriusT3 Fast UV pKa method

AN01 High quality measurements for small sample amounts

AN503 Investigation of subcutaneous monoclonal antibody formulations

AN502 IN vitro studt of subcutaneous injection of two insulin formulations

AN501 A novel in vitro model for subcutaneous injection

AN418 Using Scissor as a platform to analyze non-protein subcutaneous formulations

Pion SDi2 and Raman spectroscopy - study of diclofenac sodium salt

Understanding drug release mechanisms from diclofenac tablets using the SDi2

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

Behavior of Basic Compounds in the Presence of Plasdone Polymers

Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

Effect of Simulated Mucus Environment on the Supersaturation of Carvedilol and Its Flux through Artificial Lipophilic Membranes

Study of Danazol Cocrystal Using Trans-Membrane Flux Measurements

Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalence Studies

Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug‐Drug Interaction from pH‐Modifying Agents: Application Notes

Estimating Food Effect on Drug Absorption using Flux Experiments through Artificial Lipophilic membranes

Validation of the SDi2 intrinsic dissolution rate measurement

Using SDi2 to characterise swelling and drug release profiles

Determination of pKa values and Solubility pH Profiles of Selected ß blockers

Supersaturation in additives and GI fluids

Validation of titrimetric measurement of pKa, logP and solubility

The intrinsic solubility of indomethacin

Measuring the solubility of salts of basic drugs

Potentiometric techniques for measuring solubility at 37°C

Karl Box Sunrise Presentation

Determination of Polymer Effectiveness

Utilization of pH-Metric Titration

FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices

µDISS Profiler Brochure

µDISPENSER Brochure

µFLUX Brochure

Accessories Mesh Brochure

Accessories 30 Degrees Brochure

Studying transdermal patches using Skin PAMPA

Studying semi-solid formulations of diclofenac using Skin PAMPA

Fast pKa UV Titrations using PULSE™ Instrument

Measuring Solubility of Nanoparticles by Zero Intercept Method

Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies

Application of Skin Pampa™ to Cosmetic Solvent Screening

Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes

Biorelevant drug release of Metformin dosage forms using complementary in vitro tools

Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster

Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies

Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds

Progress in pKa Determination Technology: Case Studies in Low and High Soluble Flavonoids

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

Using Skin-PAMPA For Transdermal Patch Testing

In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles

Novel HT Method for Parallel Excipient/Vehicle Formulation Studies

Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media

Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method

Dissolution and Precipitation Monitoring of Crystalline Salts

Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions

Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen

Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder

In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds

Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds

Skin-PAMPA: Fast Prediction of Skin Penetration

Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration

Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder

Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies

Developing Skin PAMPA for Transdermal Patches

Univ Potentiometric Sensors Food Matrixes

Supersaturation and Transmembrane Flux of Meloxicam

Evaluation of Optimized Caco-2 Permeability Measurements

Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate

Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials

In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C

Univ Potentiometric Sensors Protein Binding

Nanoparticle Formulation of Gresiofulvin

Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores

Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model

Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds

Powder Intrinsic Dissolution Rate Measurement: When is it Possible?

In Situ Solubility and Dissolution of Concentrated Solutions

Drug Permeation in Skin PAMPA and Franz Cell Model

Penetration Enhancer Effect of Sucrose Esters

Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies

Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set

Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus

Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids

Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing

Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions

MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus

Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System

Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

Effect of simulated mucus environment on the supersaturation of carvedilol and its flux through artificial lipophilic membranes

Study of Danazol Cocrystal using Trans-membrane Flux Measurements

Estimating food effect on drug absorption using flux experiments through artificial lipophilic membranes

Rainbow Brochure

inForm Brochure

Scissor Brochure

SDi2 Brochure

WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution