Rainbow

Rainbow R6 Concentration Monitor

Dissolution techniques can establish more accurate correlations between in-vitro and in-vivo outcomes. Pion's Rainbow R6 world-class optical technology is increasingly regarded as a key tool in dissolution investigations.

The Rainbow R6, an in-situ fiber optic concentration monitoring system, is a powerful analytical instrument that correctly and accurately measures dissolution in real time. It is utilized for dissolution testing, flux assays, solubility studies and other applications requiring high accuracy and repeatability in concentration measurement. The Rainbow R6 is the core of Pion’s integrated microDISS and miniDISS dissolution monitoring systems, used for early phase compound screening and studies with biorelevant volumes, and FLUX systems, which improve the assessment of absorption potential. This makes it an ideal partner in biorelevant dissolution investigations. The Rainbow R6 will produce consistent, replicable results, whatever the prandial media.

Rainbow R6 is equipped with up to 8 independent fiber optic channels with data acquisition of the UV Spectra (200-720 nm) to provide concentration measurements as fast as every 2 seconds. It also offers a lower consumables cost with lamp control that turns off the UV lamp after assay completion and optionally, in between datapoints if the sampling interval exceeds 1 hour. The small instrument footprint with external 24 VDC power supply offers easy placement on lab benches. 

Additional new features, utilizing the latest AuPRO software version 7, include:

  • Extended dynamic range decreases dependency on initial probe path length selection, reduces the need to retest.
  • Easier dissolution curve interpretation with enhanced zoom function.
  • Automatic data processing feature recommends baseline correction and wavelength range parameters

Ten of the world’s top ten pharmaceutical companies use Pion’s fiber-optic technology to support dissolution measurement.

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Overview

The Rainbow Dynamic Dissolution Monitor is a powerful analytical instrument that correctly and accurately measures dissolution in real time. This makes it an ideal partner in dissolution investigations. The Rainbow R6 will produce consistent, replicable results, whatever the prandial media.

Built with a world-class optical bench, Rainbow allows for the simultaneous analysis of up to 8 vessels as fast as every 5 seconds. That means your variables can be tested more efficiently, more quickly, and to a greater degree of accuracy.

Applications

  • Real-time analysis of dissolution progress, regardless of dissolution media
  • Generates more detailed profiles
  • Simultaneous analysis for screening formulations ahead of bio-equivalence studies

Features

Individual diode array spectrometers

Programmable data collection of the entire UV spectrum, as fast as every two seconds.

8 dip-style probes

Rugged and robust stainless-steel construction for longer life and easier cleaning.

User-friendly graphic interface

For real-time data collection and analysis.

Resources

Advanced in vitro methods in generic drug product development

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AuPRO 7.0

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"miniDISS Profiler Including the *NEW* miniDT" Webinar

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"Pion MacroFLUX for Predictive Dissolution Absorption Measurements" Webinar

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"Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar

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Extended Instrument Shut Down for Pion Rainbow Storage Guidelines

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Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

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Release notes - DissoPro 3.5

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In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives

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From Traditional Dissolution to In Vivo Predictive Flux Measurements

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Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

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Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states

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Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions

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In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation

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Rainbow Brochure

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Accessories Mesh Brochure

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Accessories 30 Degrees Brochure

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Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies

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Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster

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Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies

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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus

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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System

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