Rainbow R6 Concentration Monitor
Dissolution techniques can establish more accurate correlations between in-vitro and in-vivo outcomes. Pion's Rainbow R6 world-class optical technology is increasingly regarded as a key tool in dissolution investigations.
The Rainbow R6, an in-situ fiber optic concentration monitoring system, is a powerful analytical instrument that correctly and accurately measures dissolution in real time. It is utilized for dissolution testing, flux assays, solubility studies and other applications requiring high accuracy and repeatability in concentration measurement. The Rainbow R6 is the core of Pion’s integrated microDISS and miniDISS dissolution monitoring systems, used for early phase compound screening and studies with biorelevant volumes, and FLUX systems, which improve the assessment of absorption potential. This makes it an ideal partner in biorelevant dissolution investigations. The Rainbow R6 will produce consistent, replicable results, whatever the prandial media.
Rainbow R6 is equipped with up to 8 independent fiber optic channels with data acquisition of the UV Spectra (200-720 nm) to provide concentration measurements as fast as every 2 seconds. It also offers a lower consumables cost with lamp control that turns off the UV lamp after assay completion and optionally, in between datapoints if the sampling interval exceeds 1 hour. The small instrument footprint with external 24 VDC power supply offers easy placement on lab benches.
Additional new features, utilizing the latest AuPRO software version 7, include:
- Extended dynamic range decreases dependency on initial probe path length selection, reduces the need to retest.
- Easier dissolution curve interpretation with enhanced zoom function.
- Automatic data processing feature recommends baseline correction and wavelength range parameters
Ten of the world’s top ten pharmaceutical companies use Pion’s fiber-optic technology to support dissolution measurement.
Overview
The Rainbow Dynamic Dissolution Monitor is a powerful analytical instrument that correctly and accurately measures dissolution in real time. This makes it an ideal partner in dissolution investigations. The Rainbow R6 will produce consistent, replicable results, whatever the prandial media.
Built with a world-class optical bench, Rainbow allows for the simultaneous analysis of up to 8 vessels as fast as every 5 seconds. That means your variables can be tested more efficiently, more quickly, and to a greater degree of accuracy.
Applications
- Real-time analysis of dissolution progress, regardless of dissolution media
- Generates more detailed profiles
- Simultaneous analysis for screening formulations ahead of bio-equivalence studies
Features
Individual diode array spectrometers
Programmable data collection of the entire UV spectrum, as fast as every two seconds.
8 dip-style probes
Rugged and robust stainless-steel construction for longer life and easier cleaning.
User-friendly graphic interface
For real-time data collection and analysis.
Resources
Impact of Gastric pH Variations on the Release of Amorphous Solid Dispersion Formulations Containing a Weakly Basic Drug and Enteric Polymers
Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz
Advanced in vitro methods in generic drug product development
Release notes - DissoPro 3.6 software for the Rainbow UV in-situ concentration monitor
AuPRO 7.0
"miniDISS Profiler Including the *NEW* miniDT" Webinar
"Pion MacroFLUX for Predictive Dissolution Absorption Measurements" Webinar
"Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar
Extended Instrument Shut Down for Pion Rainbow Storage Guidelines
Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine
In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives
From Traditional Dissolution to In Vivo Predictive Flux Measurements
Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states
Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions
In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation
Accessories Mesh Brochure
Accessories 30 Degrees Brochure
Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster
Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
Rainbow Brochure
Analytical Services
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