MicroDISS
Insitu fiber optic UV monitoring system for small volumes of 2- 20 ml
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Insitu fiber optic UV monitoring system for small volumes of 2- 20 ml
Designed to monitor concentration in real-time
Powered by AuPRO™
Most comprehensive dissolution data analysis software in the industry
Evaluate solubility, intrinsic disc dissolution rate, dissolution profiles, supersaturation, precipitation patterns
User-friendly graphic display
Simultaneous real-time data collection and analysis
The microDISS Profiler™ can be used to bring greater accuracy
- Small volume dissolution – tablets, capsules, powders and films
- Intrinsic dissolution of miniaturized compressed pellets
- Biorelevant dissolution
- Excipients and salts screening
- Dynamic media composition change
- Polymorphic changes and precipitation patterns
- Intrinsic and Kinetic Solubility in – Aqueous and Non-Aqueous Media
- Solution stability of drug candidates
- Nanoparticle solubility and dissolution
- Supersaturation studies
- Micro- and nanonization effects on dissolution
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Features
Versatile
Smart software and flexible architecture allow for multiple experimental conditions on a single platform.
Robust
The MicroDISS Profiler™ employs dip-style probes engineered in stainless steel.
Fast and Accurate
Up to 8 individual Photo Diode Array Spectrophotometers allow data collection of UV/VIS spectra (200 – 720 nm) at 1nm resolution as often as every two seconds from all vessels simultaneously. Allows to work with variety of volumes and stirring speeds within a single experimental set up.
Cost-effective
Ideal for small volume dissolution (2-20 mL), with interchangeable pathlength tips to bring the cost-efficiencies of combined speed and flexibility.
MicroDISS
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