The MicroDISS Profiler™ is an innovative in-situ fiber optic UV monitoring system, specifically designed to monitor small volume concentrations. It is powered by AuPRO™; the most comprehensive data analysis software in the industry.
The MicroDISS Profiler™ evaluates the various effects on solubility, intrinsic disc dissolution rate, dissolution profiles, super-saturation, precipitation profile… and more, with simultaneous real-time data collection and analysis through a user-friendly graphic display.
The MicroDISS Profiler™ can bring greater accuracy to traditional UV monitoring tasks, including:
Reduced material and media usage, along with faster turnaround time between tests.
The MicroDISS Profiler™ has dip style probes made from rugged and robust stainless steel to support accurate results, even in long-term, high-throughput use.
The individual Diode Array Spectrophotometers collect 200 – 720 nm from every channel at every timepoint.
Release notes - DissoPro 3.5
NEW Pion MiniDT- Pion’s Mini Dissolution Tester
A video introduction into MicroDISS Profiler™ instrument and its applications
Probing the mechanism of bupivacaine drug release from multivesicular liposomes
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane
Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations
Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions
AAPS2017 T5029 Particle Sizing
In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review
Kinetics of drug release from ointments: Role of transient-boundary layer
Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs
Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs
Miniaturized rotating disk intrinsic dissolution rate measurement: effects of buffer capacity in comparisons to traditional Wood’s apparatus
Miniaturized Intrinsic Dissolution Rate (Mini-IDR™) Measurement of Griseofulvin and Carbamazepine
Dissolution and Solubility (in Comprehensive Medicinal Chemistry II, Vol. 5)
Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Dissolution Media
Ketoconazole Salt and Co-crystals with Enhanced Aqueous Solubility
Solubility of sparingly-soluble drugs
Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs
Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane
µDISS Profiler Brochure
Accessories Mesh Brochure
Measuring Solubility of Nanoparticles by Zero Intercept Method
Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
Dissolution and Precipitation Monitoring of Crystalline Salts
Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies
Univ Potentiometric Sensors Food Matrixes
Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
Univ Potentiometric Sensors Protein Binding
Nanoparticle Formulation of Gresiofulvin
Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size
Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
Powder Intrinsic Dissolution Rate Measurement: When is it Possible?
In Situ Solubility and Dissolution of Concentrated Solutions
Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
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Pion's quick response time to our service needs keeps downtime to a minimum in our lab.
QC Director
Tennessee