Rainbow
The UV fiber optic-based Rainbow® Dynamic Dissolution Monitor is a powerful tool, designed to deliver the fastest path to accurate dissolution analysis. Built with a world-class optical bench, it allows for simultaneous real-time data collection and analysis of up to 8 vessels through a user-friendly software interface. It's the detection core of the MicroDISS Profiler.
DissoPRO™ is a secure, traceable software package that allows Pion’s fiber optic users to develop and run dissolution methods in a 21 CFR Part 11 compliant framework. It allows you to effortlessly save and transfer fiber-optic methods from your development lab to your QC/Compliant lab.
Explore the capabilities of our Rainbow R6.
Overview
With 20 years of proven efficiency, Pion’s Rainbow® serves as the benchmark for in situ dissolution monitoring and is widely used throughout the industry. Researchers engaged in USP dissolution and those using more novel apparatus can utilize this powerful tool to improve throughput, reduce consumables, eliminate waste streams and provide more detailed profiles. The Rainbow® also eradicates clogging, leaking and the need for pump maintenance thanks to its ability to ‘pump the light, not the liquid’.
Applications
- Traditional dissolution
- Small volume dissolution – tablets and powder
- Nanoparticle dissolution
- Intrinsic dissolution and rank order intrinsic dissolution
- USP and EU dissolution
- Biorelevant dissolution media
- Excipient screening
- Salt screening
- Stability monitoring
- Media pH change
- Dynamic media change
- Detect polymorphic changes
- Supersaturation studies
- Solubility – Aqueous and Non-Aqueous
- Follow stability profiles
- Track supersaturation effects
- Determine equilibrium solubility
- Biphasic Dissolution
- Artificial stomach duodenum monitoring
Features
Robust
The Rainbow’s dip style probes and interchangeable reflectance tips are engineered from stainless steel, with a horizontal analysis path available through the J style dip probe.
Flexible
Variable path lengths of 1, 2, 5, 10 or 20 mm for maximum flexibility.
Cost-effective
Fast return on investment due to low maintenance cost, automated data collection, and enhanced capability
Fast
Up to 8 individual Photo Diode Array Spectrophotometers allows data collection of UV/VIS spectra (200 – 720 nm) at 1nm resolution as often as every two seconds from all vessels simultaneously.
Versatile
Up to 8 data acquisition channels
Resources
Impact of Gastric pH Variations on the Release of Amorphous Solid Dispersion Formulations Containing a Weakly Basic Drug and Enteric Polymers
Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz
Advanced in vitro methods in generic drug product development
Release notes - DissoPro 3.6 software for the Rainbow UV in-situ concentration monitor
AuPRO 7.0
"miniDISS Profiler Including the *NEW* miniDT" Webinar
"Pion MacroFLUX for Predictive Dissolution Absorption Measurements" Webinar
"Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar
Extended Instrument Shut Down for Pion Rainbow Storage Guidelines
Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine
In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives
From Traditional Dissolution to In Vivo Predictive Flux Measurements
Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states
Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions
In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation
Accessories Mesh Brochure
Accessories 30 Degrees Brochure
Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster
Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
Rainbow Brochure
Consumables
Tip 1 mm Pathlength (RH)
112292
Tip 2 mm Pathlength (RH)
112293
Tip 5 mm Pathlength (RH)
112294
Tip 10 mm Pathlength (RH)
112295
Tip 20 mm Pathlength (RH)
112296
Probe Standard Length 14cm (RH)
112298
Probe Extended Length 31cm (RH thread)
120807
Probe J Style variable tip
120859
Tip C-Style 5 mm (RH)
121094
Tip C-Style 10 mm (RH)
121095
Tip C-Style 20 mm (RH)
121096
Tip C-Style 2 mm (RH)
121097
Probe Extended Length 31cm (LH thread)
112035
Tip 1 mm Pathlength (LH)
112029
Tip 2 mm Pathlength (LH)
112030
Tip 5 mm Pathlength (LH)
112031
Tip 10 mm Pathlength (LH)
112032
Tip 20 mm Pathlength (LH)
112033
Power Cord
100018
Probe Adapter - Universal
112013
Probe Adapter - J Style
120809
FO Probe Vessel Cover
120792
Fibre Optic Probe Mesh Covers
120780
Standardization Station with Magnetic Stirrer - J Probe
120929
Standardization Station with Magnetic Stirrer - Straight Probe Style
112168
MiniBath 8 Position Probe Holder
112164
USB Cable (External)
112305
Analytical Services
Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.
Resource Library
Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.
Pion's quick response time to our service needs keeps downtime to a minimum in our lab.
QC Director
Tennessee