Rainbow
Biphasic Dissolution techniques can establish more accurate correlations between in-vitro and in-vivo outcomes than conventional dissolution methods alone. Rainbow’s world-class optical technology is increasingly regarded as a key tool in biphasic dissolution investigations.
Ten of the world’s top ten pharmaceutical companies use Pion’s fibre-optic technology to support biphasic dissolution measurement.
Overview
The Rainbow dynamic dissolution monitor is a powerful analytical instrument that correctly and accurately measures dissolution in real time. This makes it an ideal partner in biphasic dissolution investigations. Rainbow will produce consistent, replicable results, whatever the biphasic dissolution media.
Built with a world-class optical bench, Rainbow allows for the simultaneous analysis of up to 8 vessels as fast as every 2 seconds. That means all your biphasic variables can be tested more efficiently, more quickly, and to a greater degree of accuracy.
Applications
- Real-time analysis of dissolution progress, regardless of dissolution media
- Generates more detailed profiles
- Simultaneous analysis for screening formulations ahead of bio-equivalence studies
Features
Individual diode array spectrometers
Programmable data collection of the entire UV spectrum, as fast as every two seconds.
8 dip-style probes
Rugged and robust stainless-steel construction for longer life and easier cleaning.
User-friendly graphic interface
For real-time data collection and analysis.
Resources
Impact of Gastric pH Variations on the Release of Amorphous Solid Dispersion Formulations Containing a Weakly Basic Drug and Enteric Polymers
Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz
Advanced in vitro methods in generic drug product development
Release notes - DissoPro 3.6 software for the Rainbow UV in-situ concentration monitor
AuPRO 7.0
"miniDISS Profiler Including the *NEW* miniDT" Webinar
"Pion MacroFLUX for Predictive Dissolution Absorption Measurements" Webinar
"Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar
Extended Instrument Shut Down for Pion Rainbow Storage Guidelines
Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine
In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives
From Traditional Dissolution to In Vivo Predictive Flux Measurements
Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states
Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions
In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation
Accessories Mesh Brochure
Accessories 30 Degrees Brochure
Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster
Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
Rainbow Brochure
Consumables
Tip 1 mm Pathlength (RH)
112292
Tip 2 mm Pathlength (RH)
112293
Tip 5 mm Pathlength (RH)
112294
Tip 10 mm Pathlength (RH)
112295
Tip 20 mm Pathlength (RH)
112296
Probe Standard Length 14cm (RH)
112298
Probe Extended Length 31cm (RH thread)
120807
Probe J Style variable tip
120859
Tip C-Style 5 mm (RH)
121094
Tip C-Style 10 mm (RH)
121095
Tip C-Style 20 mm (RH)
121096
Tip C-Style 2 mm (RH)
121097
Probe Extended Length 31cm (LH thread)
112035
Tip 1 mm Pathlength (LH)
112029
Tip 2 mm Pathlength (LH)
112030
Tip 5 mm Pathlength (LH)
112031
Tip 10 mm Pathlength (LH)
112032
Tip 20 mm Pathlength (LH)
112033
Power Cord
100018
Probe Adapter - Universal
112013
Probe Adapter - J Style
120809
FO Probe Vessel Cover
120792
Fibre Optic Probe Mesh Covers
120780
Standardization Station with Magnetic Stirrer - J Probe
120929
Standardization Station with Magnetic Stirrer - Straight Probe Style
112168
MiniBath 8 Position Probe Holder
112164
USB Cable (External)
112305
Analytical Services
Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.
Resource Library
Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.
Pion's quick response time to our service needs keeps downtime to a minimum in our lab.
QC Director
Tennessee