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MicroDISS Profiler

The MicroDISS Profiler™ is an innovative insitu fiber optic UV monitoring system, specifically designed to monitor concentration in real-time from small volume dissolution assays. It is powered by AuPRO™; the most comprehensive dissolution data analysis software in the industry.

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Overview

The MicroDISS Profiler™ is Pion’s industry recognized platform technology, which can be used to evaluate solubility, intrinsic disc dissolution rate, dissolution profiles, supersaturation, precipitation profile… and more, with simultaneous real-time data collection and analysis and a powerful yer user-friendly graphic display.

Applications

The MicroDISS Profiler™ can be used to bring greater accuracy to many pre-clinical dissolution studies, including:

  • Small volume dissolution – tablets and powder
  • Nanoparticle dissolution
  • Intrinsic dissolution
  • Biorelevant dissolution
  • Excipient and salt screening
  • Dynamic pH change
  • Polymorphic change
  • Solubility – Aqueous and Non-Aqueous
  • Follow stability profiles
  • Nanoparticle solubility
  • Supersaturation studies
  • Determine equilibrium solubility
  • Micronisation effect on dissolution

Features

Versatile

Smart software and flexible architecture allow for multiple experimental conditions on a single platform.

Robust

The MicroDISS Profiler™ employs dip-style probes engineered in stainless steel.

Fast and Accurate

Up to 8 individual Photo Diode Array Spectrophotometers allows data collection of UV/VIS spectra (200 – 720 nm) at 1nm resolution as often as every two seconds from all vessels simultaneously.

Cost-effective

Ideal for small volume dissolution (2-20 mL), with interchangeable pathlength tips to bring the cost-efficiencies of combined speed and flexibility.

Resources

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

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Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions

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AAPS2017 T5029 Particle Sizing

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In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

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Kinetics of drug release from ointments: Role of transient-boundary layer

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Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

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Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs

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Miniaturized rotating disk intrinsic dissolution rate measurement: effects of buffer capacity in comparisons to traditional Wood’s apparatus

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Miniaturized Intrinsic Dissolution Rate (Mini-IDR™) Measurement of Griseofulvin and Carbamazepine

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Dissolution and Solubility (in Comprehensive Medicinal Chemistry II, Vol. 5)

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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Dissolution Media

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Ketoconazole Salt and Co-crystals with Enhanced Aqueous Solubility

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Solubility of sparingly-soluble drugs

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Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

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Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

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µDISS Profiler Brochure

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Accessories Mesh Brochure

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Measuring Solubility of Nanoparticles by Zero Intercept Method

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Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media

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Dissolution and Precipitation Monitoring of Crystalline Salts

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Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions

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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder

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In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds

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Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds

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Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder

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Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies

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Univ Potentiometric Sensors Food Matrixes

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Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate

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Univ Potentiometric Sensors Protein Binding

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Nanoparticle Formulation of Gresiofulvin

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Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

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Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds

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Powder Intrinsic Dissolution Rate Measurement: When is it Possible?

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In Situ Solubility and Dissolution of Concentrated Solutions

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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus

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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids

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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing

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Consumables

MiniBath Magnetic Stir Bars, Disc

112125

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MiniBath Magnetic Stir Bars, Cross

112163

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Minibath Glass Vials 12mm OD Round Bottom (50)

112165

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Minibath Glass Vials 24mm OD Flat Bottom

112166

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Tip 1 mm Pathlength (RH)

112292

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Tip 2 mm Pathlength (RH)

112293

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Tip 5 mm Pathlength (RH)

112294

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Tip 10 mm Pathlength (RH)

112295

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Tip 20 mm Pathlength (RH)

112296

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Probe Standard Length 14cm (RH)

112298

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Probe Extended Length 31cm (RH thread)

120807

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Probe J Style variable tip

120859

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Tip C-Style 5 mm (RH)

121094

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Tip C-Style 10 mm (RH)

121095

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Tip C-Style 20 mm (RH)

121096

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Tip C-Style 2 mm (RH)

121097

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Probe Extended Length 31cm (LH thread)

112035

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Tip 1 mm Pathlength (LH)

112029

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Tip 2 mm Pathlength (LH)

112030

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Tip 5 mm Pathlength (LH)

112031

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Tip 10 mm Pathlength (LH)

112032

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Tip 20 mm Pathlength (LH)

112033

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Power Cord

100018

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Probe Adapter - Universal

112013

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Probe Adapter - J Style

120809

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FO Probe Vessel Cover

120792

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Fibre Optic Probe Mesh Covers

120780

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Standardization Station with Magnetic Stirrer - J Probe

120929

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Standardization Station with Magnetic Stirrer - Straight Probe Style

112168

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MiniBath 8 Position Probe Holder

112164

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USB Cable (External)

112305

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Analytical Services

Analytical Services

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Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

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Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

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Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

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