Pre-Formulation
Once the Discovery phase has identified promising candidates for development, it is essential to carry out comprehensive Pre-formulation studies, if successful drug development is to result. Until the behaviour of a new API has been analysed and stress-tested under various conditions, it is impossible to progress to a robust dosage form. Pion works with companies and academic departments around the world to support Pre-formulation studies. We’ll provide the test results to inform your research, together with analysis and interpretation, if required.
Miniaturised Dissolution
Miniaturized dissolution assays can help scientists make decisions during early stages of the drug development cycle – from pure API to early formulation strategies.
MicroFLUX
MicroFLUX™ allows you to combine data from a dissolution experiment with transmembrane permeation. It is the perfect in vitro tool to support pharmacokinetic (PK) prediction and decision-making.
IDR
Pion’s miniature dissolution equipment is capable of measuring the Intrinsic Dissolution Rate (IDR) for solid compounds you submit for analysis and has applications in ranking candidates during salt selection and solid form screening.
IDR Imaging
Enabling the imaging and measurement of intrinsic dissolution and release rates using very small sample amounts.
Biorelevant Dissolution
Pion can characterise dissolution and solubility behaviour in biorelevant media simulating different zones and compositions within the human body.
Biphasic Dissolution
Pion has developed a biphasic dissolution assay to mimic dissolution and absorption within the human gastrointestinal tract (GIT).
Solubility
Work with Pion to get all the solubility test results you need to understand your drug's behavior, and establish the profiles of candidates you’ll wish to develop further.
Biorelevant Solubility
The level of solubility in biorelevant media representing Fasted State and Fed State Simulated Intestinal Fluids (FaSSIF and FeSSIF) are key physchem properties to identify and understand.
Excipient Screening
Combining excipients with active compounds can improve their solubility, bioavailability and more. But which excipients will work best with your candidate compounds?
Supersaturation
Pion’s tests accurately measure supersaturation and can determine the amorphous or kinetic solubility level of your API in aqueous solution.
Precipitation Inhibition Enhancement
Pion’s tests accurately measure for precipitation/non-precipitation in vitro, allowing you to predict how precipitation inhibitors will effect absorption in vivo.
pKa
We use aqueous or cosolvent approaches, and optimise the analysis conditions and perform repeat analyses until the best result is achieved.
LogP and LogD
Pion’s gold standard pH-metric and shake-flask PhysChem assays yield the LogP and LogD of compounds.
Surface Activity CMC
Wettability, dissolution and solubility, selection of formulation ingredients, and drug absorption can all be influenced by drugs with surface active properties.
PAMPA
Pion’s PAMPA technology measures passive permability using various membranes to mimic gastro-intestinal conditions, or the blood-brain or human skin barrier.
PAMPA Excipients
PAMPA can also be used to assess the impact of solubility enhancing ingredients on the overall flux behaviour of poorly soluble drugs.
Scientific Instruments
We provide novel in-vitro tools that promote quicker, more informed decision-making.
Resource Library
Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.