Once the Discovery phase has identified promising candidates for development, it is essential to carry out comprehensive Pre-formulation studies, if successful drug development is to result. Until the behaviour of a new API has been analysed and stress-tested under various conditions, it is impossible to progress to a robust dosage form. Pion works with companies and academic departments around the world to support Pre-formulation studies. We’ll provide the test results to inform your research, together with analysis and interpretation, if required.
Miniaturized dissolution assays can help scientists make decisions during early stages of the drug development cycle – from pure API to early formulation strategies.
MicroFLUX™ allows you to combine data from a dissolution experiment with transmembrane permeation. It is the perfect in vitro tool to support pharmacokinetic (PK) prediction and decision-making.
Pion’s miniature dissolution equipment is capable of measuring the Intrinsic Dissolution Rate (IDR) for solid compounds you submit for analysis and has applications in ranking candidates during salt selection and solid form screening.
Enabling the imaging and measurement of intrinsic dissolution and release rates using very small sample amounts.
Pion can characterise dissolution and solubility behaviour in biorelevant media simulating different zones and compositions within the human body.
Pion has developed a biphasic dissolution assay to mimic dissolution and absorption within the human gastrointestinal tract (GIT).
Work with Pion to get all the solubility test results you need to understand your drug's behavior, and establish the profiles of candidates you’ll wish to develop further.
The level of solubility in biorelevant media representing Fasted State and Fed State Simulated Intestinal Fluids (FaSSIF and FeSSIF) are key physchem properties to identify and understand.
Combining excipients with active compounds can improve their solubility, bioavailability and more. But which excipients will work best with your candidate compounds?
Pion’s tests accurately measure supersaturation and can determine the amorphous or kinetic solubility level of your API in aqueous solution.
Pion’s tests accurately measure for precipitation/non-precipitation in vitro, allowing you to predict how precipitation inhibitors will effect absorption in vivo.
We use aqueous or cosolvent approaches, and optimise the analysis conditions and perform repeat analyses until the best result is achieved.
Pion’s gold standard pH-metric and shake-flask PhysChem assays yield the LogP and LogD of compounds.
Wettability, dissolution and solubility, selection of formulation ingredients, and drug absorption can all be influenced by drugs with surface active properties.
Pion’s PAMPA technology measures passive permability using various membranes to mimic gastro-intestinal conditions, or the blood-brain or human skin barrier.
PAMPA can also be used to assess the impact of solubility enhancing ingredients on the overall flux behaviour of poorly soluble drugs.