Mini DeBEE
The Mini DeBEE crosses over from R&D work to small-scale production and offers the highest process intensity in the industry
PAMPA
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability.
LOREM IPSUM
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
LOREM IPSUM
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
The Mini DeBEE crosses over from R&D work to small-scale production and offers the highest process intensity in the industry
The perfect crossover between R&D and pilot scale
Unparalleled formulation discovery
Increased flow capacities for direct scalability
Features
Operating pressure:
Available in either 2,000 - 30,000 PSI or 2,000 - 45,000 PSI[TS1]
(2000 Bar /3100 Bar)
Flow rate:
Up to 4.0 GPH (15 LPH) at 45,000 KPSI
Up to 5.3 GPH (20 LPH) at 30,000 KPSI
THE PION PAMPA ADVANTAGE
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In Vivo Correlation
Gut-Box controls stirring speed to match the hydrodynamics of the intestinal tract or the blood brain barrier. The adjustable stirring allows you to mimic the ABL (aqueous boundary layer), allowing for higher accuracy and reducing assay time.[1].
High Throughput
The STIRWELL plates in Pions’ PAMPA sandwich kits contain a pre-loaded stir bar in each well, providing dynamic stirring for each assay, allowing for high-throughput screening of multiple compounds simultaneously.
Easy Data Interpretation
PAMPA Explorer software for easy data
interpretation. SW includes a plate-reader
data wizard, results visualization, and reporting. Data output is the complete mass balance including membrane retention.
Reproducible Results
While orbital shakers can lead to edge
effects in the assay plates, GutBox provides consistent agitation across the whole plate, allowing for more reproducible data.
Complete Solution
The complete PAMPA system includes our 96well STIRWELL plates, the Gut Box™ stirring system and PAMPA Explorer™ software.
Pion’s PAMPA is an in vitro, high throughput screening assay highly correlated to biological membrane permeability
Screening excipients, solvents, and APIs to rank order formulations and drug candidates on the basis of permeability.
Each PAMPA well uses artificial lipid membranes that mimic drug uptake in the gastrointestinal tract (GIT) or the blood-brain barrier(BBB) to provide robust, reliable, bio relevant results.
Proven to achieve industry leading results for cell lysis, nano emulsions and dispersions, and particle size reduction:
- High-yield cell lysis
- Improve product stability
- Increase bioavailability
- Tighter particle size distribution
Applications:
- Cell rupture with the highest yield
- Particle size reduction
- Stable micro / nano emulsions & dispersions
- Guaranteed scalability
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Mini DeBEE
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