physchem analysis.svg

Physicochemical Analysis Tools

The results of PhysChem analysis form the foundations on which much of the process of drug development is based. Expertise in PhysChem analysis is also one of the principles on which Pion was founded and where we’ve continued to build our reputation. We provide the instrumentation and expertise that allow scientists and researchers around the world to establish the core properties of the compounds they are working with. Our key strengths in PhysChem Analysis cover ionization, pKa, LogP, Solubility, Dissolution and Permeability.

IonizationLogP and LogDSolubility

Our Technologies

Pion's range of versatile instruments is designed to automate the analysis of physicochemical properties. They can help assess overlapping KPAs and collect insights on dissolution, solubility, and permeability. With insights from our PhysChem analysis tools, researchers can reduce errors and make better formulation choices.

sirius t3.svg

SiriusT3 for Ionization

A fully automated tool for compound screening via PhysChem analysis, using small scale samples.

See more
sirius t3.svg

SiriusT3 for LogP and LogD

A fully automated tool for compound screening via PhysChem analysis, using small scale samples.

See more
microdiss profiler.svg

MicroDISS Profiler for Solubility

Pion’s in-situ fiber-optic monitoring system provides real-time concentration or percent dissolved versus time data.

See more
sirius t3.svg

SiriusT3 for Solubility

A fully automated tool for compound screening and PhysChem analysis, using small sample amounts.

See more
inform.svg

inForm for Solubility

A powerful and versatile instrument for automated analysis of solutions, compounds and formulations.

See more

What Is Physicochemical Analysis?

Physicochemical analysis is instrumental in measuring the ability of a chemical compound to produce a pharmacological effect. By examining the interactions between a drug and a biomolecule, researchers can assess whether the drug is delivering its intended effects or further improvements are required. Physicochemical analysis of drugs offers a faster way to acquire essential data and facilitate pharmaceutical development.

Physicochemical Properties of Drugs

  • Solubility: depends on a variety of factors such as temperature, pH, pressure, and nature of solute and solvent. 
  • Surface activity: Surface active agents influence drug absorption which is based on the surfactant’s chemical nature and concentration.
  • Partition coefficient: affects the way the drug gets transported from the site of application to site of action. 
  • Ionization of drug: depends on its pKa & pH. Ionization influences the degree of penetration of a drug through membranes.
  • Protein binding: Depending on whether it’s acidic or basic, a drug can either bind to multiple or single blood proteins.
  • Hydrogen bonding: a crucial parameter in the formulation of drugs, hydrogen bonding is classified into two types: intermolecular and intramolecular.

Your Trusted Research Partners

State-of-the-Art Tools

Our center of excellence for production in the U.S. holds an ISO 9001:2015 certification; all of our products meet the highest quality standards.

Service and Aftercare

All Pion equipment is backed by an initial one-year warranty. Our service team is trained to increase equipment lifespan and retain the value of your investment.

Thorough Analysis

We can run standardized tests, assays, analysis and interpretation that are essential to your progress.

Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

Find out more

Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

Find out more

Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

Find out more

Pion's quick response time to our service needs keeps downtime to a minimum in our lab.

QC Director
Tennessee

Close