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Permeability

PAMPA’s 96-well plate-based patented technology allows you to predict the permeability of your compounds in vitro with far greater efficiency, while only requiring small amounts of potentially scarce material.

PAMPA delivers reliable and reproducible results via an artificial membrane, which is immobilized on a filter and placed between donor and acceptor compartments.  At the start of a test, a drug is introduced into the donor compartment, either as a solid, formulation or neat solution in the form of a DMSO stock. Then, following the permeation period, the concentration of drug is measured in the donor and the acceptor compartments.

See our library for extensive publications on PAMPA in peer-reviewed journals, written in collaboration with academics and pharmaceutical scientists. These include Dr. Manfred Kansy (Hoffman-La Roche, CH), founder of the PAMPA method and Pion’s founder, Alex Avdeef. 

Pion Permeability Devices

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PAMPA for Permeability

An efficient high-throughput tool to measure passive transmembrane permeability and flux – skin, blood-brain, and GIT.

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Gut-Box for Permeability

A special stirring device that improves the accuracy and reliability of your PAMPA solubility and permeability assays.

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TempPlate for Permeability

TempPlate A simple cost-effective solution for accurate temperature control during plate incubation, with straightforward touchscreen controls.

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Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

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Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

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Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

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