Pion’s MicroFLUX™ allows you to combine data from a dissolution experiment with transmembrane permeation. It is the perfect in vitro tool to support pharmacokinetic (PK) prediction and decision-making.
The MicroFLUX™ offers a novel solution to conducting small volume in situ concentration monitoring, while at the same time evaluating the absorption potential of your compound as the receiver and donor chambers are separated with a membrane. The MicroFLUX™ also allows you to control for temperature and stirring.
Pion’s MicroFLUX™ system is a convenient and powerful in vitro tool with a range of applications:
During the pharmaceutical development process, many formulation vehicles are evaluated for the enhancement of solubility. However, the effect on net FLUX may not be evaluated until there is an uptake issue in pre-clinical trial. With the MicroFLUX™ system, you can simultaneously evaluate changes in solubility with changes in FLUX before the pre-clinical phase.
In attempts to characterise the transport of a drug product within the body in vitro, researchers often use a variety of media change experiments to assess alterations in solubility with pH. Historically, changes in FLUX that relate to these changes in solubility have been difficult to study. The Micro-FLUX™ system offers you a reliable way to assess these effects.
"Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar
Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane
Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds
From Traditional Dissolution to In Vivo Predictive Flux Measurements
Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods
Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds
Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes
Investigating the driving force of membrane transport of carvedilol from supersaturated solutions achieved by ...
In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review
in vitro dissolution-absorption evaluation of an electrospun cyclodextrin-based formulation of aripiprazole using µFLUX
Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions
Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane
Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane
Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane
FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices
µFLUX Brochure
Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes
Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes
In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles
Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
Supersaturation and Transmembrane Flux of Meloxicam
Nanoparticle Formulation of Gresiofulvin
Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions
Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques
Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
Effect of simulated mucus environment on the supersaturation of carvedilol and its flux through artificial lipophilic membranes
Study of Danazol Cocrystal using Trans-membrane Flux Measurements
Estimating food effect on drug absorption using flux experiments through artificial lipophilic membranes
1208008
1208006
1208004
120802
120854
120871
120872
120873
120874
120875
121107
112163
121248
IM_uFLUX
Pion's quick response time to our service needs keeps downtime to a minimum in our lab.
QC Director
Tennessee