MicroFLUX

Overview

The MicroFLUX™ offers a novel solution to conducting small volume in situ concentration monitoring, while at the same time evaluating the absorption potential of your compound as the receiver and donor chambers are separated with a membrane. The MicroFLUX™ also allows you to control for temperature and stirring.

Applications

Pion’s MicroFLUX™ system is a convenient and powerful in vitro tool with a range of applications:

Assessing the effect different formulation vehicles have on FLUX
Assessing pre-clinical performance based on pH or food
Correlating dissolution results to in vivo absorption

Features

Time-saving

During the pharmaceutical development process, many formulation vehicles are evaluated for the enhancement of solubility. However, the effect on net FLUX may not be evaluated until there is an uptake issue in pre-clinical trial. With the MicroFLUX™ system, you can simultaneously evaluate changes in solubility with changes in FLUX before the pre-clinical phase.

Problem-solving

In attempts to characterise the transport of a drug product within the body in vitro, researchers often use a variety of media change experiments to assess alterations in solubility with pH. Historically, changes in FLUX that relate to these changes in solubility have been difficult to study. The Micro-FLUX™ system offers you a reliable way to assess these effects.

Resources

"Pion Biphasic Dissolution PBPK Modelling and Lipolysis Assays" Webinar

Evaluating side‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

From Traditional Dissolution to In Vivo Predictive Flux Measurements

Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes

Investigating the driving force of membrane transport of carvedilol from supersaturated solutions achieved by ...

In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

in vitro dissolution-absorption evaluation of an electrospun cyclodextrin-based formulation of aripiprazole using µFLUX

Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions

Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices

µFLUX Brochure

Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes

Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles

Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

Supersaturation and Transmembrane Flux of Meloxicam

Nanoparticle Formulation of Gresiofulvin

Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions

Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

Effect of simulated mucus environment on the supersaturation of carvedilol and its flux through artificial lipophilic membranes

Study of Danazol Cocrystal using Trans-membrane Flux Measurements

Estimating food effect on drug absorption using flux experiments through artificial lipophilic membranes