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MicroFLUX

Pion’s MicroFLUX™ allows you to combine data from a dissolution experiment with transmembrane permeation. It is the perfect in vitro tool to support pharmacokinetic (PK) prediction and decision-making.

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Overview

The MicroFLUX™ offers a novel solution to conducting small volume in situ concentration monitoring, while at the same time evaluating the absorption potential of your compound as the receiver and donor chambers are separated with a membrane. The MicroFLUX™ also allows you to control for temperature and stirring.

Applications

Pion’s MicroFLUX™ system is a convenient and powerful in vitro tool with a range of applications:

  • Assessing the effect different formulation vehicles have on FLUX
  • Assessing pre-clinical performance based on pH or food
  • Correlating dissolution results to in vivo absorption

Features

Time-saving

During the pharmaceutical development process, many formulation vehicles are evaluated for the enhancement of solubility. However, the effect on net FLUX may not be evaluated until there is an uptake issue in pre-clinical trial. With the MicroFLUX™ system, you can simultaneously evaluate changes in solubility with changes in FLUX before the pre-clinical phase.

Problem-solving

In attempts to characterise the transport of a drug product within the body in vitro, researchers often use a variety of media change experiments to assess alterations in solubility with pH. Historically, changes in FLUX that relate to these changes in solubility have been difficult to study. The Micro-FLUX™ system offers you a reliable way to assess these effects.

Resources

Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

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Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

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From Traditional Dissolution to In Vivo Predictive Flux Measurements

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Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

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Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

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Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes

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Investigating the driving force of membrane transport of carvedilol from supersaturated solutions achieved by ...

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In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

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in vitro dissolution-absorption evaluation of an electrospun cyclodextrin-based formulation of aripiprazole using µFLUX

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Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions

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Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

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Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

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Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

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FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices

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µFLUX Brochure

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Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes

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Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

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In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles

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Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

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Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

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Supersaturation and Transmembrane Flux of Meloxicam

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Nanoparticle Formulation of Gresiofulvin

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Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions

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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

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Effect of simulated mucus environment on the supersaturation of carvedilol and its flux through artificial lipophilic membranes

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Study of Danazol Cocrystal using Trans-membrane Flux Measurements

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Estimating food effect on drug absorption using flux experiments through artificial lipophilic membranes

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Assay part number

MicroFLUX, 4 Pair (8 chamber)

1208008

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MicroFLUX, 3 Pair (6 chamber)

1208006

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MicroFLUX, 2 Pair (4 chamber)

1208004

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MicroFLUX GIT Reagent Kit

120802

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Test Compounds for FLUX apparatus

120854

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MicroFLUX Membrane Holder-Male (each)

120871

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MicroFLUX Membrane Holder-Female (each)

120872

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MicroFLUX Teflon Washers (pack of 20)

120873

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MicroFLUX Viton O-Rings (pack of 25)

120874

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MicroFLUX PVDF Membrane (Pack of 25)

120875

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FLUX Plastic Disposable Cell Pairs (Qty 4)

121107

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MiniBath Magnetic Stir Bars, Cross

112163

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Two Position Cover for MicroFLUX Thermal Block

121248

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Instruction Manual for MicroFLUX

IM_uFLUX

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Analytical Services

Analytical Services

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Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

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Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

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Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

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