MacroFLUX™

Overview

In many cases, dissolution experiments alone cannot predict the in vivo response of drug products due to the complicated interplay of solubility and permeability in complex media. By introducing a stirred absorption chamber into familiar dissolution apparatus, Pion’s MacroFLUX allows you to extend the utility of in situ concentration monitoring and reach the required data density for accurate assessment of transmembrane FLUX.

Applications

Pion’s MacroFLUX™ device improves the assessment of absorption potential, providing for:

Real time IVIVC prediction
Improved modelling due to greater data density
In situ concentration monitoring for real-time decision making
More accurate prediction before moving on into animal studies

Features

Accuracy

In a case study using MacroFLUX™ to compare the dissolution and flux results of an innovator and a generic product, the in vitro result (showing the generic at 71% of the flux of the innovator) revealed excellent correlation with the in vivo data (at 72%) taken from bioequivalence studies .

Resources

Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

From Traditional Dissolution to In Vivo Predictive Flux Measurements

Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states

MacroFLUX DDI

The effect of formulation additives on in vitro dissolution-absorption profile and in vivo bioavailability of telmisartan from brand and generic formulations

Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products

Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects

MacroFLUX Generics

Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalence Studies

Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug‐Drug Interaction from pH‐Modifying Agents: Application Notes

FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices

Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies

Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster

Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies

MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus