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MacroFLUX™

With Pion’s MacroFLUX™  device, you can reliably test and rank the absorption potential of formulations and finished drug products in vitro. This is accomplished using a standard USP dissolution set-up coupled with an absorption chamber along with fiber optic UV detection and can greatly enhance in vivo prediction.

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Overview

In many cases, dissolution experiments alone cannot predict the in vivo response of drug products due to the complicated interplay of solubility and permeability in complex media. By introducing a stirred absorption chamber into familiar dissolution apparatus, Pion’s MacroFLUX allows you to extend the utility of in situ concentration monitoring and reach the required data density for accurate assessment of transmembrane FLUX.

Applications

Pion’s MacroFLUX™  device improves the assessment of absorption potential, providing for:

  • Real time IVIVC prediction
  • Improved modelling due to greater data density
  • In situ concentration monitoring for real-time decision making
  • More accurate prediction before moving on into animal studies 

Features

Accuracy

In a case study using MacroFLUX™  to compare the dissolution and flux results of an innovator and a generic product, the in vitro result (showing the generic at 71% of the flux of the innovator) revealed excellent correlation with the in vivo data (at 72%) taken from bioequivalence studies .

Resources

Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

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From Traditional Dissolution to In Vivo Predictive Flux Measurements

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Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

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Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

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Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states

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MacroFLUX DDI

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The effect of formulation additives on in vitro dissolution-absorption profile and in vivo bioavailability of telmisartan from brand and generic formulations

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Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products

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Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects

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MacroFLUX Generics

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Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalence Studies

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Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug‐Drug Interaction from pH‐Modifying Agents: Application Notes

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FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices

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Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies

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Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster

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Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies

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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus

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Consumables

MacroFLUX Mini Fibre Optic Probe 10 mm

121091

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MacroFLUX Mini Fibre Optic Probe 5 mm

121092

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MacroFLUX Mini Fibre Optic Probe 2 mm

121093

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MacroFLUX Evaporation Plug

121129

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MacroFLUX Absorption Chamber Stirrer Assembly

121130

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MacroFLUX Acceptor Chamber with attached PVDF membrane

121136

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MacroFLUX Vessel Cover-Universal (primary & secondary segments with Evap Plug)

121325

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MacroFLUX Storage Bottle, 100mL

121192

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Analytical Services

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Products at a glance

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Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

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Resource Library

Resource Library

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