With Pion’s MacroFLUX™ device, you can reliably test and rank the absorption potential of formulations and finished drug products in vitro. This is accomplished using a standard USP dissolution set-up coupled with an absorption chamber along with fiber optic UV detection and can greatly enhance in vivo prediction.
In many cases, dissolution experiments alone cannot predict the in vivo response of drug products due to the complicated interplay of solubility and permeability in complex media. By introducing a stirred absorption chamber into familiar dissolution apparatus, Pion’s MacroFLUX allows you to extend the utility of in situ concentration monitoring and reach the required data density for accurate assessment of transmembrane FLUX.
Pion’s MacroFLUX™ device improves the assessment of absorption potential, providing for:
In a case study using MacroFLUX™ to compare the dissolution and flux results of an innovator and a generic product, the in vitro result (showing the generic at 71% of the flux of the innovator) revealed excellent correlation with the in vivo data (at 72%) taken from bioequivalence studies .
Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds
From Traditional Dissolution to In Vivo Predictive Flux Measurements
Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods
Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds
Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states
The effect of formulation additives on in vitro dissolution-absorption profile and in vivo bioavailability of telmisartan from brand and generic formulations
Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products
Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects
Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalence Studies
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug‐Drug Interaction from pH‐Modifying Agents: Application Notes
FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices
Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies
Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster
Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
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