Surface imaging is an increasingly important tool in effective drug development, and the SDI2 puts scientists right there at the interface, enabling you to monitor the dissolution of APIs in real time – and also to record the process for subsequent analysis. The SDI2 captures the action in both the visible light and the UV spectrum.
The SDi2 features a powerful 4.2 megapixel ActiPixTM detector to capture both ultra-violet and visible surface imaging, as it happens. The SDi2 generates high-resolution 2-D videos that show these dynamic processes in real time. Reviewing the videos allows scientists to gain a full understanding of exactly what’s happening as the surface breaks down.
SDI2 gives scientists the ability to...
Real-time UV and visible light intensities are captured by the built-in Actipix™ detector providing a detailed, spatial view of the dissolution process directly at the solid-solution interface; a view that is unattainable with conventional dissolution methods. The dual wavelength capability allows for the measurement of drug concentration and monitoring of the physical processes in a single experiment.
The small scale and whole dosage flow cells can be quickly and conveniently exchanged, making the system suitable for a wide range of pharmaceutical development applications.
Dissolution media can be automatically changed at a pre-defined time during any experiment, for example, from gastric to intestinal pH media. Built-in flushing and cleaning procedures make for ease of use and help avoid cross contamination in the flow through set-up.
Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations
Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms
Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions
Development of a novel method utilising dissolution imaging for the measurement of swelling behaviour in hydrophilic matrices
UV imaging in pharmaceutical analysis
Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging
Application of UV Imaging in Formulation Development
Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination
Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging
Simultaneous UV Imaging and Raman Spectroscopy for the Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing
Detection of poor acid resistance of enteric coats using the SDI
AAPS Advanced imaging, detection and prediction of initial gel formation and swelling of hypromellose compacts
Direct imaging of the dissolution of salt forms of a carboxylic acid drug
Evaluation of in vitro tests to reduce animal testing in drug toxicology studies
Faster Dissolution Methods
Low Volume Dissolution Assays
The effect of dissolution media, torque and flow speed
AAPS Understanding drug release mechanisms of metformin using complementary in vitro dissolution tools
Visualising the release patterns of promethazine across microparticulate systems
Use of SDI to assess dissolution characteristics - John Comer (Pion)
Application of the SDI in Pharmaceuticals - Mei Wong (Pfizer)
Characteristics of Felodipine ‐ HPMCAS Solid Dispersions
Understanding drug release mechanisms from diclofenac tablets using the SDi2
Validation of the SDi2 intrinsic dissolution rate measurement
Using SDi2 to characterise swelling and drug release profiles
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools
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