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Mini-Bath (MB8)

The Mini-Bath is a robust instrument specifically designed for small volume, parallel dissolution experiments. It allows researchers to generate IDR and other dissolution curves with ease using limited quantities of material.

The Mini-Bath usually forms part of the MicroDISS™  package but is also available as a standalone item.

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Overview

Traditional dissolution baths are not well-suited to some applications, such as formulation development, especially with time or sample constraints. The Mini-Bath lets you scale down your dissolution testing for powders, suspensions and formulations and for intrinsic dissolution rate testing, with independent stirring control in up to eight miniaturized vessels. This means you can gather meaningful dissolution data from minute quantities of API, or formulated API.

Applications

The Mini-Bath (MB8) can be used for:

  • Small volume dissolution of tablets and powder - as low as 1mL and up to 20mL
  • Nanoparticle dissolution
  • Intrinsic dissolution
  • Biorelevant dissolution
  • Excipient and salt screening
  • Stability monitoring and media pH change
  • Dynamic PH change
  • Polymorph screening
  • Solubility – Aqueous and Non-Aqueous
  • Follow stability profiles
  • Supersaturation studies and tracking
  • Determine equilibrium solubility
  • Micro suspension

Features

Versatility

Internal individual motors allows for precise independent stirring control, while external temperature control lets you run experiments at a wide range of temperatures.

Cost-effectiveness

Working with small quantities  of API a few mg means more tests can be performed at an earlier stage in the development process means less time is taken and less material is required than tradi-tional methods.

Resources

Release notes - DissoPro 3.5

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NEW Pion MiniDT- Pion’s Mini Dissolution Tester

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A video introduction into MicroDISS Profiler™ instrument and its applications

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Probing the mechanism of bupivacaine drug release from multivesicular liposomes

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

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In Situ Fiber Optic Dissolution Monitoring of Combination Drug Product Containing Three Actives

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Using Biorelevant Flux Measurements for Prediction of Fraction Absorbed for the Drug Products of Poorly Soluble Compounds

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Simultaneous in situ monitoring of free drug concentration and nanoparticles during dissolution testing of nanocrystalline and amorphous formulations

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From Traditional Dissolution to In Vivo Predictive Flux Measurements

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Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods

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Simultaneous Determination of Intrinsic Solubility Simultaneous Determination of Intrinsic Solubility and pK of Ionizable Pharmaceutical Compounds

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Spectrophotometric pKa Determination of Ionizable Pharmaceuticals: Resolution of Molecules with Weak pH-Dependent Spectral Shift

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Design and development of a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations

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Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

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Biorelevant Flux Measurements And Prediction Of Fraction Absorbed For The Drug Products Of Poorly Soluble Compounds

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Tailored on demand anti-coagulant dosing: An in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms

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Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states

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Comparison of Cinchona Catalysts Containing Ethyl or Vinyl or Ethynyl Group at Their Quinuclidine Ring

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pKa and physchem property measurements for the pharmaceutical industry

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AuPRO Comparison Flyer

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Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions

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Development of a novel method utilising dissolution imaging for the measurement of swelling behaviour in hydrophilic matrices

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Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. I. Description of a two-phase in vitro dissolution test

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Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test

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Toward Biorelevant Dissolution: Application of a Biphasic Dissolution Model as a Discriminating Tool for HPMC Matrices Containing a Model BCS Class II Drug

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Overcoming sink limitations in dissolution testing:a review of traditional methods and the potential utility of biphasic systems

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Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus

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In vivo predictive mini-scale dissolution for weak bases: Advantages of pH-shift in combination with an absorptive compartment

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Evaluation of a biphasic in vitro dissolution test for estimating the bioavailability of carbamazepine polymorphic forms

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Development of a discriminative biphasic in vitro dissolution test and correlation with in vivo pharmacokinetic studies for differently formulated racecadotril granules

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Development of a biphasic dissolution test for Deferasirox dispersible tablets and its application in establishing an in vitro-in vivo correlation

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In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review

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Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts

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Developing Quantitative In Vitro-In Vivo Correlation for Fenofibrate Immediate-Release Formulations With the Biphasic Dissolution-Partition Test Method

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Discriminatory Potential Of Biphasic Medium Over Compendial And Biorelevant Medium For Assessment Of Dissolution Behavior Of Tablets Containing Meloxicam Nanoparticles

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Selection of a discriminant and biorelevant in vitro dissolution test for the development of fenofibrate self-emulsifying lipid-based formulations

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Dissolution of poorly water-soluble drugs in biphasic media using USP 4 and fiber optic system

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Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics

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Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: Polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs

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Insight into the Development of Dissolution Media for BCS Class II Drugs: A Review from Quality Control and Prediction of In Vivo Performance Perspectives

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Application of a Biphasic Test for Characterization of In Vitro Drug Release of Immediate Release Formulations of Celecoxib and Its Relevance to In Vivo Absorption

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Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. II. Improved in vitro-in vivo correlation using a two-phase dissolution test

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Biorelevant test for supersaturable formulation

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A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model

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Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation

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Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site

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A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

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Mechanistic Study of Belinostat Oral Absorption From Spray-Dried Dispersions

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UV imaging in pharmaceutical analysis

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Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging

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Application of UV Imaging in Formulation Development

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Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination

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LogP as a tool in intramolecular hydrogen bond considerations

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Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging

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Simultaneous UV Imaging and Raman Spectroscopy for the Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing

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Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

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Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes

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Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method

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Dissolution rate of ciprofloxacin and its cocrystal with resorcinol

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Acid‐base titrations of proteins in small volumes

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The impact of cosolvent on measured log P values

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Determination of hydrogen bonding properties using logP

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AAPS Advanced imaging, detection and prediction of initial gel formation and swelling of hypromellose compacts

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Understanding the self-assembly process of industrially relevant co-crystals

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Studying Crystallisation & Dissolution Processes Using Particle Size & Shape Analysis

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AAPS2017 T5029 Particle Sizing

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High-throughput phospholipidosis screening

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Surface tension and supersaturation

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Approaches for measuring intestinal precipitation rates of oral drugs

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Approaches for measuring intestinal precipitation rates

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Measuring the isoelectric point of peptides by potentiometric titration

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Investigating the driving force of membrane transport of carvedilol from supersaturated solutions achieved by ...

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MacroFLUX DDI

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Solubility Measurement

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Measuring Physiochemical Properties

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PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement

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WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution

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WEBINAR: Measuring solubility - what’s best for you?

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WEBINAR: Physicochemical Properties and their relation to ADMET

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WEBINAR: How Cheqsol Works

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WEBINAR: Investigating Supersaturation and Solubility Enhancement

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The behaviour of drug formulations under biorelevant and biphasic conditions

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WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs

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WEBINAR: State of the art UV methods for measuring pKa

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WEBINAR: Accessing hydrogen bond parameters and their application in drug discovery

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WEBINAR: Log P- History, Measurement and Applications in Drug Development

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WEBINAR: In vitro measurement of drug bioavailability following subcutaneous injection

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WEBINAR: Interesting results from our Analytical Services department

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In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

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Kinetics of drug release from ointments: Role of transient-boundary layer

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Novel oral formulation approach for poorly water-soluble drug using lipocalin-type prostaglandin D synthase

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Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process

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Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro-in vivo evaluations

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Crystal Structure and Physicochemical Characterization of Ambazone Monohydrate, Anhydrous, and Acetate Salt Solvate

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Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

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Powder Dissolution Method for Estimating Rotating Disk Intrinsic Dissolution Rates of Low Solubility Drugs

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Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

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Miniaturized rotating disk intrinsic dissolution rate measurement: effects of buffer capacity in comparisons to traditional Wood’s apparatus

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Miniaturized Intrinsic Dissolution Rate (Mini-IDR™) Measurement of Griseofulvin and Carbamazepine

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Dissolution and Solubility (in Comprehensive Medicinal Chemistry II, Vol. 5)

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In situ fiber optic dissolution monitoring of vitamin B12 solid dosage formulation

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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Dissolution Media

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Spectrophotometric pKa determination of ionizable pharmaceuticals: Resolution of molecules with weak pH-dependent spectral shift

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Drug ionization and physicochemical profiling

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pH-metric solubility. 3. Dissolution titration template method for solubility determination

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pH-Metric Solubility. 2. Correlation Between the Acid-Base Titration and the Saturation Shake-Flask Solubility-pH Methods

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Structure-lipophilicity relationships of neutral and protonated b-blockers, part I: intra and intermolecular effects in isotropic solvent systems

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Octanol-, Chloroform-, and PGDP-Water Partitioning of Morphine-6-Glucuronide and Other Related Opiates

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pH-Metric logP. 4. Comparison of Partition Coefficients Determined by HPLC and Potentiometric Methods to Literature Values

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Determination of Protonation Macro- and Microconstants and Octanol/Water Partition Coefficient of Antiinflammatory Niflumic Acid

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A Versatile Potentiometric Analyzer, Part Two: Multiple Known Addition and Gran Titration Techniques

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A Versatile Potentiometric Analyzer, Part One: Hardware, the User Interface, and Titration Techniques

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Weighting Scheme for Regression Analysis Using pH Data from Acid-Base Titrations

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Bjerrum Plots for the Determination of Systematic Concentration Errors in Titration Data

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Accurate Measurements of the Concentration of Hydrogen Ions with a Glass Electrode: Calibrations Using the Prideaux and Other Universal Buffer Solutions and a Computer-Controlled Automatic Titrator

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Ketoconazole Salt and Co-crystals with Enhanced Aqueous Solubility

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Solubility-Excipient Classification Gradient Maps

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Solubility of sparingly-soluble drugs

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A measured solution

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Factors influencing the water solubility of crystalline drugs. (in Drug Bioavailability. Estimation of Solubility, Permeability, Absorption and Bioavailability)

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in vitro dissolution-absorption evaluation of an electrospun cyclodextrin-based formulation of aripiprazole using µFLUX

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Investigation of the Efficacy of Transdermal Penetration Enhancers Through the Use of Human Skin and a Skin Mimic Artificial Membrane

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P-Glycoprotein Deficient Mouse in situ Blood-Brain Barrier Permeability and its Prediction using an in combo PAMPA Model

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The permeation of amphoteric drugs through artificial membranes - an in combo absorption model based on paracellular and transmembrane permeability

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Coexistence of passive and active carrier-mediated uptake processes in drug transport: a more balanced view

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Study on permeability enhancing effect of new ceramide-analogues by PAMPA method

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How well can the Caco-2/MDCK models predict effective human jejunal permeability?

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Absorption-Excipient-pH Classification Gradient Maps: Sparingly-Soluble Drugs and the pH Partition Hypothesis

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Membrane-water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel

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Permeation of permanently charged molecules through artificial membranes - influence of physicochemical properties

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PAMPA—critical factors for better predictions of absorption

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PAMPA - a Drug Absorption in vitro Model. 13. Chemical Selectivity due to Membrane Hydrogen Bonding: in combo Comparisons of HDM-, DOPC-, and DS-PAMPA

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HT solubility and permeability: MAD-PAMPA analysis. (in Pharmacokinetic Profiling in Drug Reasearch: Biological, Physicochemical, and Computational Strategies)

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PAMPA-Excipient Classification Gradient Maps

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Caco-2 Permeability of Weakly Basic Drugs Predicted with the Double-Sink PAMPA pKa flux Method

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Advances in Screening for Membrane Permeability: High-Resolution PAMPA for Medicinal Chemists

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Assessing the Impact of Polymers on the pH-Induced Precipitation Behavior of Poorly Water-Soluble Compounds using Synchrotron Wide Angle X-Ray Scattering

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Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

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Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

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Novel N-methylsulfonamide and Retro-N-methylsulfonamide Derivatives as 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors with Good ADME-Related Physicochemical Parameters

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Physico-chemical Profiling of the ACE-inhibitor Lisinopril: Acidbase Properties

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Solubility-pH Profiles of some Acidic, Basic and Amphoteric Drugs

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Partial Protection Against Multiple RT-SHIV162P3 Vaginal Challenge of Rhesus Macaques by a Silicone Elastomer Vaginal Ring Releasing the NNRTI MC1220

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pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties

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Acidity and Hydrophobicity of Several New Potential Antitubercular Drugs: Isoniazid and Benzimidazole Derivatives

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Physicochemical investigation of the influence of saccharide-based parenteral formulation excipients on l-p-boronphenylalanine solubilisation for boron neutron capture therapy

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Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists

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The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions

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Study of pH-dependent solubility of organic bases. Revisit of Henderson-Hasselbalch relationship. Anal Chim Acta 2010, 673 (1), 40-46. * Comer, J., Supersaturation effects in drug development

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Structural and thermodynamic analyses of alpha-L-fucosidase inhibitors

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New ideas about the solubility of drugs

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The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides

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Using measured pKa, LogP and solubility to investigate supersaturation and predict BCS class

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The chemistry of multi-protic drugs Part 1: A potentiometric, multi-wavelength UV and NMR pH titrimetric study of the micro-speciation of SKI-606

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The Rise of PAMPA

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PAMPA - a drug absorption in vitro model. 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones

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Absorption using the PAMPA Approach (in Optimization in Drug Discovery: In Vitro Methods)

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PAMPA - a Drug Absorption in vitro Model. 8. Apparent Filter Porosity and the Unstirred Water Layer

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Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine

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PAMPA - a Drug Absorption in vitro Model. 11. Matching the in vivo Unstirred Water Layer Thickness by Individual-Well Stirring in Microtitre Plates

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Acid-Base Cosolvent Method for Determining Aqueous Permeability of Amiodarone, Itraconazole, Tamoxifen, Terfenadine and Other Very Insoluble Molecules

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In vitro permeability of poorly aqueous soluble compounds using different solubilizers in the PAMPA assay with liquid chromatography/mass spectrometry detection

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PAMPA - a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa flux - optimized design (pOD-PAMPA)

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In vitro trans-monolayer permeability calculations: often forgotten assumption

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The effect of formulation additives on in vitro dissolution-absorption profile and in vivo bioavailability of telmisartan from brand and generic formulations

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Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions

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Utilizing In Vitro Dissolution-Permeation Chamber for the Quantitative Prediction of pH-Dependent Drug-Drug Interactions with Acid-Reducing Agents: a Comparison with Physiologically Based Pharmacokinetic Modeling

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Fast Simultaneous Determination of logP and pKa by Potentiometry: para- Alkoxyphenol Series (Methoxy to Pentoxy)

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Cadmium binding by biological ligands. Part 4. Polynuclear complexes of cadmium with 2,3-dimercaptopropane-1-sulphonic acid

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pH‐Metric log P. Part 1. Difference Plots for Determining Ion‐Pair Octanol‐Water Partition Coefficients of Multiprotic Substances

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pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances

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pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances.

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Measurement of pKa and logP of Water-Insoluble Substances by Potentiometric Titration

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pH-metric logP. 6. Effects of Sodium, Potassium and N-CH3-D-Glucamine on the Octanol-Water Partioning of Prostaglandins E1 and E2

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Influence of two fatty amine surfactants on foliar absorption, translocation and efficacy of 2,4-D triethanolamine salt

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Fungicidal activity of N-(2-cyano-2-methoxiaminoacetyl) amino acids and their derivatives

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The prediction of the lipophilicity of peptidomimetics. A comparison between experimental and theoretical lipophilicty values of renin inhibitors and their building blocks

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Validation of pH-Metric Technique for Measurement of pKa and logPow of Ionizable Herbicides

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Limits for Successful Measurement of pKa and logP by pH-Metric Titration

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Interlaboratory study of logP determination by shake-flask and potentiometric methods

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Assessment of distribution- pH profiles

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Ionization and Partitioning Profiles of Zwitterions: The Case of the Anti-Inflammatory Drug Azapropazone

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1-octanol/water partition coefficient (Kow) amd pKa for ionizable pesticides measured by a pH-metric method

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Practical aspects of partition measurements according to GLP rules

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Lipophilicity profiles of ampholytes

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Lercanidipine: short plasma half-life, long duration of action and high cholesterol tolerance. Updated molecular model to rationalize its pharmacokinetic properties

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5-(piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1, 4-benzodiazepines: High-affinity, basic ligands for the cholecystokinin-B receptor

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Quantitative structure-activities among macrolide antibacterial agents: in vitro and in vivo potency against Pasturella Multicoda

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Lipophilicity behaviour of model and medicinal compounds containing a sulfide, sulfoxide, or sulfone moiety

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pH electrode performance under automated management conditions

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Potentiometric pKa determination of water-insoluble compounds. Validation study in methanol/water mixtures

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pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs

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Mechanisms of liposomes/water partitioning pf (p-methylbenzyl) alkylamines

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Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

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Considerations on the potentiometric logP determination

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Multiwavelength spectrophotometric determination of acid dissociation constants of ionisable drugs

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pH-metric logP 11. pKa determination of water-insoluble drugs in organic solvent- water mixtures

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Multiwavelength spectrophotometric determination of acid dissociation constants. Part IV. Water-insoluble pyridine derivatives

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Multiwavelength spectrophotometric determination of acid dissociation constants Part III. Resolution of multi-protic ionization systems

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Multiwavelength spectrophotometric determination of acid dissociation constants: Part II. First derivative vs. target factor analysis

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Determination of liposome partitioning of ionizable drugs by titration

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N-substituted analogues of S-nitroso-N-acetypenicillamine: chemical stability and prolonged nitric oxide mediated vasodilation in isolated rat femoral arteries

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Drug liposome partitioning as a tool for the prediction of Human passive intestinal absorption

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Ionization constants and distribution coefficients of phenothiazines and calcium channel antagonists determined by a pH-metric method and correlation with calculated partition coefficients

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BUFMAKE: a computer program to calculate the compositions of buffers of defined buffer capacity and ionic strength for ultra-violet spectrophotometry

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Structure-lipophilicity relationships of neutral and protonated-blockers, part I: intra and intermolecular effects in isotropic solvent systems

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Multiwavelength spectrophotometric determination of acid dissociation constants Part VI. Deconvolution of binary mixtures of ionizable compounds

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Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as a model compound

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Multiwavelength spectrophotometric determination of acid dissociation constants Part V. Tautomerization microcontstants

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Physicochemical characterization of sildenafil: Ionization, lipophilicity behaviour, and ionic-partition diagram studied by two-phase titration and electrochemistry

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Rapid Physicochemical Profiling as an Aid to Drug Candidate Selection

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Solubility challenge: can you predict solubilities of 32 molecules using a database of 100 reliable measurements?

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Multiwavelength Spectrophotometric Resolution of the Micro- equilibria of a Triprotic Amphoteric Drug: Methacycline

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Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants: A Validation Study

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Concomitant hydrate polymorphism in the precipitation of sparfloxacin from aqueous solution.

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Multiwavelength Spectrophotometric Resolution of the Micro-Equilibria of Cetirizine

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A new method for the reproducible generation of polymorphs: two forms of sulindac with very different solubilities.

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Lipophilicity behaviour of the zwitterionic antihistamine cetirizine in phospatidylcholine liposomes/water systems

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Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors

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High throughput physicochemical profiling for drug discovery

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Lipophilicity Profiles: Theory and Measurement

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Diclofenac Solubility: Independent Determination of the Intrinsic Solubility of Three Crystal Forms

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Physicochemical Properties of a New Multicomponent Cosolvent System for the pKa Determination of Poorly Soluble Pharmaceutical Compounds.

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Potentiometric and spectrophotometric pKa determination of water-insoluble compounds: Validation study in a new cosolvent system. Anal. Chim

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Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

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Presentation of a Structurally Diverse and Commercially Available Drug Data Set for Correlation and Benchmarking Studies

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Calculation of Abraham Descriptors from solvent-water partition coefficients in four different systems; evaluation of different methods of calculation

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A new multi-wavelength spectrophotometric method for the determination of the molar absorption coefficients of ionisable drugs

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Application of hydrogen bonding calculations in property based drug design

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Equilibrium vs. kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution - a validation study

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New findings on the synthesis of the centrally acting muscle relaxant chlormezanone and its resolution of a gram scale using a Chiralcel OD column

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Hydantoin-Substituted 4,6-Dichloroindole-2- carboxylic Acids as Ligands with High Affinity for the Glycine Binding Site of the NMDA Receptor

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Ionization Constants and Ionization profiles

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Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties

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A potentially simpler approach to measure aqueous pKa of insoluble basic drugs containing amino groups

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Physical and molecular properties of agrochemicals: an analysis of screen inputs, hits, leads and products

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Ionization, Lipophilicity and solubility properties of repaglinide

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Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases.

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High Throughput Measurement of pKa values in a mixed-buffer linear pH gradient system

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High Throughput measurement of drug pKa values for ADME screening

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A modification of the Hammett equation for predicting ionization constants of p-vinyl phenols.

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High throughput measurement of logD and pKa In Drug Bioavailability. Estimation of Solubility, Permeability and Bioavailability

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Permeability through DOPC/dodecane membranes: measurement and LFER modelling

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Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products

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Direct imaging of the dissolution of salt forms of a carboxylic acid drug

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Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

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In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

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Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation

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A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model

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Video: Use of Flux Measurements in Lieu of In Vitro Dissolution to Assess the Complex Interplay Between Solubility, Permeability and Formulation Effects

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Scissor subcutaneous poster

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Subcutaneously administered biopharmaceuticals

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MacroFLUX Generics

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Measuring Physiochemical Properties 2

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4‐case chart to classify supersaturation and precipitation behavior

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Measuring pKa values in 2-propanol to gain process understanding

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Ionization Constants of Isoniazid and Benzimidazole

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pH-metric titration to characterize aci-nitro tautomerism

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Effects of solubility enhancing excipients

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A DoE study to understand partition rate in a biphasic system

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Evaluation of in vitro tests to reduce animal testing in drug toxicology studies

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Faster Dissolution Methods

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Low Volume Dissolution Assays

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The effect of dissolution media, torque and flow speed

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Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation

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Supersaturation time with CheqSol using different excipients AZ

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Supersaturation, phase separation and measurement of precipitation rates

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AAPS 2017 Supersaturation excipients poster KBox

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AAPS 2017 Supersaturation modelling poster KBox

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Biorelevant dissolution - the quest for simple in-vitro experiments

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AAPS Understanding drug release mechanisms of metformin using complementary in vitro dissolution tools

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AAPS 2017 Flo-Vitro poster KBox

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A pH stat method to measure the dissolution rate of nano- and microparticle suspensions

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Visualising the release patterns of promethazine across microparticulate systems

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Biphasic dissolution studies of Felodipine

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Dissolution & precipitation studies of carbamazepine cocrystals with small scale assays

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Dissolution of a drug in the presence of additives and biorelevant media

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Dissolution in presence of lipid to mimic absorption

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Dissolution Experiments in Lipid Layers

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Small scale assays for studying dissolution of cocrystals

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Small volume dissolution of a poorly soluble drug as solid dispersions

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In-situ pH change on a biphasic dissolution model in the presence of SIFs

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Use of SDI to assess dissolution characteristics - John Comer (Pion)

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Application of the SDI in Pharmaceuticals - Mei Wong (Pfizer)

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Dissolution Imaging Symposium 2013 - Book of Abstracts

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Solubility of drugs in the presence of excipients in lipid based formulations

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Supersaturation & precipitation of ionizable drugs with cellulose polymers

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Physicochemical Studies of Triclosan

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Simulated Lung Fluid media

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Solubility measurement by extrapolation

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Solubilities of morphine analogs

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Biphasic dissolution studies: Impact of concentration and particle size on partition rate

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Improvements in biphasic dissolution

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Biphasic dissolution studies of Aripiprazole

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Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution

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Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution

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Characteristics of Felodipine ‐ HPMCAS Solid Dispersions

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Dissolution Performance of Inhaled Products in Simulated Lung Fluid

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In-situ Solubility Measurements of Ionizable Drugs

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Determination of Aqueous Solubility by Extrapolation

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A low volume method for screening Plasdone® polymers

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Assay Expert Flyer

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SDi Digest

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Biphasic Dissolution Case Study of Carvedilol

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Salts Dissolution

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A pH stat method to measure the dissolution rate of nano- and microparticle suspensions

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Biphasic Dissolution Studies

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BCS Class IV formulation: case study

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Triclosan: a PhysChem study

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AN405 Controlled supersaturation by solvent-quench

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AN404 Biorelevant dissolution with gradient pH adjustment

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AN403 GI lipolysis of lipid based drug formulations

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AN402 Controlled supersaturation assays for modelling intestinal precipitation

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AN401 Biphasic Dissolution

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Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt

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AN410 Measuring the isoelectric point pf peptides by potentiometric titration

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AN15 Determination of pKa Measurement or Prediction?

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AN14 Using NaOH and NaCL instead of KOM and KCI

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AN13 Measuring Solubility What’s Best for You?

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AN12 Introduction to logP and logD Measurement Using SiriusT3

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AN11 Evaluating Solid Dispersion using Small-Scale Dissolution Testing

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AN10 Measuring LogP of Samples that are Hard to Dissolve in Water and Octanol

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AN09 The Determination of Solubility - Pion CheqSol Explained

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AN08 Solubility and Supersaturation - A Brief Introduction

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AN07 the Pion GI Dissolution Assay

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AN06 The use of cosolvent pKa assays for poorly soluble compounds

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AN05 Measurement of extreme pKas

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AN04 Insights into BCS classification using Pion assays

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AN03 Blank Titrations Using the SiriusT3

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AN02 PKa measurements in 15 minutes - the SiriusT3 Fast UV pKa method

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AN01 High quality measurements for small sample amounts

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AN503 Investigation of subcutaneous monoclonal antibody formulations

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AN502 IN vitro studt of subcutaneous injection of two insulin formulations

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AN501 A novel in vitro model for subcutaneous injection

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AN418 Using Scissor as a platform to analyze non-protein subcutaneous formulations

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Pion SDi2 and Raman spectroscopy - study of diclofenac sodium salt

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Understanding drug release mechanisms from diclofenac tablets using the SDi2

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membrane

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Behavior of Basic Compounds in the Presence of Plasdone Polymers

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Differentiating Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane

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Effect of Simulated Mucus Environment on the Supersaturation of Carvedilol and Its Flux through Artificial Lipophilic Membranes

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Study of Danazol Cocrystal Using Trans-Membrane Flux Measurements

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Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalence Studies

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Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug‐Drug Interaction from pH‐Modifying Agents: Application Notes

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Estimating Food Effect on Drug Absorption using Flux Experiments through Artificial Lipophilic membranes

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Validation of the SDi2 intrinsic dissolution rate measurement

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Using SDi2 to characterise swelling and drug release profiles

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Determination of pKa values and Solubility pH Profiles of Selected ß blockers

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Supersaturation in additives and GI fluids

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Validation of titrimetric measurement of pKa, logP and solubility

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The intrinsic solubility of indomethacin

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Measuring the solubility of salts of basic drugs

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Potentiometric techniques for measuring solubility at 37°C

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Karl Box Sunrise Presentation

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Determination of Polymer Effectiveness

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Utilization of pH-Metric Titration

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FLUX Measurements using Pion µFLUX™ and MacroFLUX™ Devices

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µDISS Profiler Brochure

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µDISPENSER Brochure

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µFLUX Brochure

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Rainbow Brochure

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Accessories Mesh Brochure

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Accessories 30 Degrees Brochure

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inForm Brochure

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Scissor Brochure

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SDi2 Brochure

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Studying transdermal patches using Skin PAMPA

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Studying semi-solid formulations of diclofenac using Skin PAMPA

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Fast pKa UV Titrations using PULSE™ Instrument

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Measuring Solubility of Nanoparticles by Zero Intercept Method

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Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies

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Application of Skin Pampa™ to Cosmetic Solvent Screening

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Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes

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Biorelevant drug release of Metformin dosage forms using complementary in vitro tools

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Using Integrated Absorption Chamber with USP II Dissolution Apparatus to Predict Risk of Drug-Drug Interaction from pH Modifying Agents: Poster

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Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies

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Using flux experiments through artificial lipophilic membranes for predicting food effect for BCS Class 2 Compounds

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Progress in pKa Determination Technology: Case Studies in Low and High Soluble Flavonoids

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Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes

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Using Skin-PAMPA For Transdermal Patch Testing

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In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles

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Novel HT Method for Parallel Excipient/Vehicle Formulation Studies

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Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments

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Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media

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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media

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Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method

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Dissolution and Precipitation Monitoring of Crystalline Salts

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Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions

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Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen

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Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder

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In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds

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Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds

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Skin-PAMPA: Fast Prediction of Skin Penetration

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Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration

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Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder

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Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies

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Developing Skin PAMPA for Transdermal Patches

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Univ Potentiometric Sensors Food Matrixes

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Supersaturation and Transmembrane Flux of Meloxicam

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Evaluation of Optimized Caco-2 Permeability Measurements

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Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate

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Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials

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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C

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Univ Potentiometric Sensors Protein Binding

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Nanoparticle Formulation of Gresiofulvin

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Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores

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Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model

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Miniaturization of Powder Dissolution Measurement and Estimation of Particle Size

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Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds

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Powder Intrinsic Dissolution Rate Measurement: When is it Possible?

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In Situ Solubility and Dissolution of Concentrated Solutions

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Drug Permeation in Skin PAMPA and Franz Cell Model

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Penetration Enhancer Effect of Sucrose Esters

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Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies

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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus

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Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set

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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus

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Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids

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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing

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Universal Potentiometric Sensors Fast Determination of Free Ionized Drug Concentration in Micellar Solutions

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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus

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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System

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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles

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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX

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Dissolution, Free Drug Concentration and Permeability of Crystalline Nanoparticle Formulation Study Using In Situ Fiber Optic and Potentiometric Techniques

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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids

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Effect of simulated mucus environment on the supersaturation of carvedilol and its flux through artificial lipophilic membranes

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Study of Danazol Cocrystal using Trans-membrane Flux Measurements

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Estimating food effect on drug absorption using flux experiments through artificial lipophilic membranes

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