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inForm

inForm is a versatile formulation workstation that fills the gap between research-based micro-scale dissolution and the compendial world. It allows for precise pH control and monitoring, enabling you to study dissolution under conditions that mimic in vivo conditions more closely that other systems.

inForm can be used to provide biorelevant dissolution and solubility data to help you make formulation decisions more effectively.

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Overview

inForm enables innovative methods such as biphasic dissolution, gradient pH adjustment and controlled supersaturation to show how a drug would behave under biorelevant conditions. It can accommodate multiple dosage forms and sample types with quantitation by in-situ UV-dip probes. There is also the built-in option to automatically remove aliquots for off-line quantitative analysis. Notably, inForm also includes the industry standard UV-metric and pH-metric methods for the determination of pKa and solubility for ionizable substances featured on the Sirius T3. This enables extensive physchem characterization for your API and its formulations.

Applications

inForm is a highly versatile platform, designed to offer a suite of automated dissolution and supersat-uration testing tools, which together provide:

  • Biorelevant and traditional multi step dissolution assays with pH control
  • Built-in assays, including dissolution, biphasic dissolution and pH-metric dissolution
  • Ability to study API or formulated samples
  • Physchem characterization for drug compounds
  • Evaluation of the effects of excipients and other formulation additives on sample solubility and the duration and extent of supersaturated states

Features

Relevance

inForm provides high-quality support for formulation development, reflecting industry’s growing interest in dissolution to support in vivo prediction.

Part of the Pion Dissolution Family

Pion products are engineered to work together to simplify dissolution challenges.

Part of the Pion suite of PhysChem Analysis Tools

Pion products are engineered to work together to support PhysChem Analysis.

Versatility

inForm assays are capable of handling samples as powders, granules or whole dosage forms; liquids can be solutions, suspensions and low viscosity lipid-based formulations.

inForm assays allow the user to control instrument functions such as data collection rate, assay dura-tion, automatic pH control, methods of sample introduction and more.

Precision

inForm’s precision engineered hardware ensures fluid and sample additions are tightly controlled by high accuracy fluid dispensers. Assay stirring speeds are kept consistent and temperature is constant-ly managed. This means that experiments performed on inForm are highly reproducible.

The built-in spectrophotometer allows for the UV quantitation of samples across multiple wave-lengths simultaneously, while also enabling the deconvolution and quantitation of multi-component samples. Variable path length tips are also available to suit compounds with sparing or extreme UV absorbance.

inForm’s software fully tracks and records temperature, spectra, pH, and reagent volumes for every data point of every assay, providing a wealth of information for all instrument applications.

Robotics

inForm has a fully automated X, Y and Z axis on both arms, allowing you to run complicated assays that would be challenging to set up manually. The probe arm is equipped to facilitate complete automa-tion, enabling instrument-controlled reagent addition, temperature control, spectra collection, pH measurement, and sample addition. The vial arm allows sequences of up to 20 assays to be queued and is also equipped with a sampling needle capable of introducing liquid samples or collecting ali-quots from running assays for offline analysis.

Resources

Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

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Understanding the self-assembly process of industrially relevant co-crystals

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Approaches for measuring intestinal precipitation rates of oral drugs

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Approaches for measuring intestinal precipitation rates

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PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement

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WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution

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The behaviour of drug formulations under biorelevant and biphasic conditions

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WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs

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In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review

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The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions

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4‐case chart to classify supersaturation and precipitation behavior

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A DoE study to understand partition rate in a biphasic system

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Evaluation of in vitro tests to reduce animal testing in drug toxicology studies

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Faster Dissolution Methods

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Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation

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Supersaturation time with CheqSol using different excipients AZ

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Supersaturation, phase separation and measurement of precipitation rates

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AAPS 2017 Supersaturation excipients poster KBox

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AAPS 2017 Supersaturation modelling poster KBox

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Biorelevant dissolution - the quest for simple in-vitro experiments

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In-situ pH change on a biphasic dissolution model in the presence of SIFs

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Physicochemical Studies of Triclosan

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Biphasic dissolution studies: Impact of concentration and particle size on partition rate

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Improvements in biphasic dissolution

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Biphasic dissolution studies of Aripiprazole

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Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution

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Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution

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Biphasic Dissolution Case Study of Carvedilol

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Salts Dissolution

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A pH stat method to measure the dissolution rate of nano- and microparticle suspensions

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Biphasic Dissolution Studies

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BCS Class IV formulation: case study

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Triclosan: a PhysChem study

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AN405 Controlled supersaturation by solvent-quench

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AN404 Biorelevant dissolution with gradient pH adjustment

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AN403 GI lipolysis of lipid based drug formulations

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AN402 Controlled supersaturation assays for modelling intestinal precipitation

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AN401 Biphasic Dissolution

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Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt

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AN09 The Determination of Solubility - Pion CheqSol Explained

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AN08 Solubility and Supersaturation - A Brief Introduction

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AN07 the Pion GI Dissolution Assay

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inForm Brochure

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Consumables

Basket

00115-0178

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Silicon Rubber Disc for 3mm tablet - Pack of 10

00302-0007

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Silicon Rubber Disc for 6mm tablet - Pack of 10

00302-0008

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Silicon Rubber Disc for 8mm tablet - Pack of 10

00302-0009

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inFORM Vial

00304-0001

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T3 - 50 mL Syringe

00306-0001

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10ml syringe

00306-0002

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5ml syringe

00306-0003

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Cap Piercing Needle

00306-0010

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inFORM Capillary Assembly

00306-0020

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Deuterium Lamp

00409-0001

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inFORM Electrode

00485-0002

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Filling solution for inFORM Electrode

01402-0001

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inFORM Peltier Assembly

01015-0004

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5mm path length tip

00408-0004

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10mm path length tip

00408-0005

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20mm path length tip

00408-0006

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Silicon Rubber Disc for 3mm tablet - Pack of 10

00302-0007

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Silicon Rubber Disc for 6mm tablet - Pack of 10

00302-0008

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Silicon Rubber Disc for 8mm tablet - Pack of 10

00302-0009

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3mm Tablet Disc - Pack of 5

00115-0170

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6mm Tablet Disc - Pack of 5

00115-0171

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8mm Tablet Disc - Pack of 5

00115-0172

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Sirius Tablet Press

01202-0001

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Analytical Services

Analytical Services

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Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

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Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

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Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

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