inForm is a versatile formulation workstation that fills the gap between research-based micro-scale dissolution and the compendial world. It allows for precise pH control and monitoring, enabling you to study dissolution under conditions that mimic in vivo conditions more closely that other systems.
inForm can be used to provide biorelevant dissolution and solubility data to help you make formulation decisions more effectively.
inForm enables innovative methods such as biphasic dissolution, gradient pH adjustment and controlled supersaturation to show how a drug would behave under biorelevant conditions. It can accommodate multiple dosage forms and sample types with quantitation by in-situ UV-dip probes. There is also the built-in option to automatically remove aliquots for off-line quantitative analysis. Notably, inForm also includes the industry standard UV-metric and pH-metric methods for the determination of pKa and solubility for ionizable substances featured on the Sirius T3. This enables extensive physchem characterization for your API and its formulations.
inForm is a highly versatile platform, designed to offer a suite of automated dissolution and supersat-uration testing tools, which together provide:
inForm provides high-quality support for formulation development, reflecting industry’s growing interest in dissolution to support in vivo prediction.
Pion products are engineered to work together to simplify dissolution challenges.
Pion products are engineered to work together to support PhysChem Analysis.
inForm assays are capable of handling samples as powders, granules or whole dosage forms; liquids can be solutions, suspensions and low viscosity lipid-based formulations.
inForm assays allow the user to control instrument functions such as data collection rate, assay dura-tion, automatic pH control, methods of sample introduction and more.
inForm’s precision engineered hardware ensures fluid and sample additions are tightly controlled by high accuracy fluid dispensers. Assay stirring speeds are kept consistent and temperature is constant-ly managed. This means that experiments performed on inForm are highly reproducible.
The built-in spectrophotometer allows for the UV quantitation of samples across multiple wave-lengths simultaneously, while also enabling the deconvolution and quantitation of multi-component samples. Variable path length tips are also available to suit compounds with sparing or extreme UV absorbance.
inForm’s software fully tracks and records temperature, spectra, pH, and reagent volumes for every data point of every assay, providing a wealth of information for all instrument applications.
inForm has a fully automated X, Y and Z axis on both arms, allowing you to run complicated assays that would be challenging to set up manually. The probe arm is equipped to facilitate complete automa-tion, enabling instrument-controlled reagent addition, temperature control, spectra collection, pH measurement, and sample addition. The vial arm allows sequences of up to 20 assays to be queued and is also equipped with a sampling needle capable of introducing liquid samples or collecting ali-quots from running assays for offline analysis.
Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods
Understanding the self-assembly process of industrially relevant co-crystals
Approaches for measuring intestinal precipitation rates of oral drugs
Approaches for measuring intestinal precipitation rates
PODCAST: Precipitation Behaviour of Weakly Basic Compounds - Solubility and Dissolution Enhancement
WEBINAR: Pion inForm - a new instrument for investigating solubility and dissolution
The behaviour of drug formulations under biorelevant and biphasic conditions
WEBINAR: In-vitro approaches for investigating intestinal precipitation of oral drugs
In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review
The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions
4‐case chart to classify supersaturation and precipitation behavior
A DoE study to understand partition rate in a biphasic system
Evaluation of in vitro tests to reduce animal testing in drug toxicology studies
Faster Dissolution Methods
Controlled supersaturation by the solvent quench method, with UV monitoring of precipitation
Supersaturation time with CheqSol using different excipients AZ
Supersaturation, phase separation and measurement of precipitation rates
AAPS 2017 Supersaturation excipients poster KBox
AAPS 2017 Supersaturation modelling poster KBox
Biorelevant dissolution - the quest for simple in-vitro experiments
In-situ pH change on a biphasic dissolution model in the presence of SIFs
Physicochemical Studies of Triclosan
Biphasic dissolution studies: Impact of concentration and particle size on partition rate
Improvements in biphasic dissolution
Biphasic dissolution studies of Aripiprazole
Robert Taylor: Automated Measurements of Lipolysis, Supersaturation & Biphasic Dissolution
Automated Measurements of Precipitation, Supersaturation and Biphasic Dissolution
Biphasic Dissolution Case Study of Carvedilol
A pH stat method to measure the dissolution rate of nano- and microparticle suspensions
Biphasic Dissolution Studies
BCS Class IV formulation: case study
Triclosan: a PhysChem study
AN405 Controlled supersaturation by solvent-quench
AN404 Biorelevant dissolution with gradient pH adjustment
AN403 GI lipolysis of lipid based drug formulations
AN402 Controlled supersaturation assays for modelling intestinal precipitation
AN401 Biphasic Dissolution
Pion inForm Intrinsic Dissolution Rate of Ibuprofen and its Sodium Salt
AN09 The Determination of Solubility - Pion CheqSol Explained
AN08 Solubility and Supersaturation - A Brief Introduction
AN07 the Pion GI Dissolution Assay
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