The level of aqueous solubility and solubility in biorelevant media of any API are key physchem properties to identify in Pre-Formulation studies. Additionally solubility excipient screening helps overcome the challenge of identifying one or more suitable excipients to improve the in-vivo performance of your compounds.
That’s where Pion comes in. We’ve been leaders in solubility for nearly 20 years now, and we can run the tests you need to ascertain the solubility profiles of your candidates, so you are ready to move forward into formulation with all the information you need.
Work with Pion to get all the solubility test results you need to understand your drug's behavior, and establish the profiles of candidates you’ll wish to develop further.
The level of solubility in biorelevant media representing Fasted State and Fed State Simulated Intestinal Fluids (FaSSIF and FeSSIF) are key physchem properties to identify and understand.
Combining excipients with active compounds can improve their solubility, bioavailability and more. But which excipients will work best with your candidate compounds?
Pion’s tests accurately measure supersaturation and can determine the amorphous or kinetic solubility level of your API in aqueous solution.
Pion’s tests accurately measure for precipitation/non-precipitation in vitro, allowing you to predict how precipitation inhibitors will effect absorption in vivo.