PhysChem
The results of PhysChem analysis are critical in the Pre-Formulation phase of drug development. And expertise in PhysChem analysis is a key competency for Pion. We provide the test results that allow scientists and researchers around the world to model and predict the behaviors of the APIs they are working with. Our key strengths in PhysChem Analysis for pre-formulation cover pKa, LogP, solubility, permeability and surface activity.
PhysChem Analytical Services
pKa
We use aqueous or cosolvent approaches, and optimise the analysis conditions and perform repeat analyses until the best result is achieved.
LogP and LogD
Pion’s gold standard pH-metric and shake-flask PhysChem assays yield the LogP and LogD of compounds.
Surface Activity CMC
Wettability, dissolution and solubility, selection of formulation ingredients, and drug absorption can all be influenced by drugs with surface active properties.
PAMPA
Pion’s PAMPA technology measures passive permability using various membranes to mimic gastro-intestinal conditions, or the blood-brain or human skin barrier.
PAMPA Excipients
PAMPA can also be used to assess the impact of solubility enhancing ingredients on the overall flux behaviour of poorly soluble drugs.
Scientific Instruments
We provide novel in-vitro tools that promote quicker, more informed decision-making.
Resource Library
Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.