Dissolution

MicroFLUX

In-vitro assessment of dissolution-absorption processes in a low-volume environment for early-stage ranking of in-vivo outcomes.

MicroFLUX product imageMicroFLUX product imageMicroFLUX product image
MicroFLUX product imageMicroFLUX product imageMicroFLUX product image
benefits

In-vitro assessment of dissolution-absorption processes in a low-volume environment for early-stage ranking of in-vivo outcomes

Low Volume Dissolution-Absorption testing

Utilizing the Pion Rainbow for in-situ real-time measurement

Simultaneous assessment of drug substance

Combine Dissolution and Absorption measurements into a single assay

MicroFLUX

Configurations

Rapid evaluation

Low-volume absorption chamber

The MicroFLUX™ device consists of a low-volume absorption chamber separated from a low-volume donor chamber with a biomimetic gastrointestinal tract permeation membrane. Compatible with a wide range of aqueous and biorelevant medias, the MicroFLUX can be used for rapid evaluation of sample performance under a variety of conditions with a low media and sample burden.

The impact of excipients on drug behavior when conducting these simultaneous dissolution-absorption studies provides an understanding of the complex interplay between solubility, permeability, and dissolution rate in-vitro and establishes the MicroFLUX as a valuable tool for ranking in vivo outcomes.

Low-volume absorption chamber
Low-volume absorption chamber

UV probes from the Rainbow Dynamic Dissolution Monitor® instrument.
Dynamic Dissolution

UV probes from the Rainbow Dynamic Dissolution Monitor® instrument.

Fiber-optic UV probes are positioned in both the donor and receiver compartments allowing real-time dissolution and absorption concentration monitoring in both chambers. Concentration monitoring is enabled by connecting the fiber optic UV probes from the Rainbow Dynamic Dissolution Monitor® instrument. AuPRO software contains dissolution and absorption curve modeling tools to calculate dissolution rate and flux parameters without the need to external data processing or calculation.