The results of PhysChem analysis are critical in the Pre-Formulation phase of drug development. And expertise in PhysChem analysis is a key competency for Pion. We provide the test results that allow scientists and researchers around the world to model and predict the behaviors of the APIs they are working with. Our key strengths in PhysChem Analysis for pre-formulation cover pKa, LogP, solubility, permeability and surface activity.
We use aqueous or cosolvent approaches, and optimise the analysis conditions and perform repeat analyses until the best result is achieved.
Pion’s gold standard pH-metric and shake-flask PhysChem assays yield the LogP and LogD of compounds.
Pion’s PAMPA technology measures passive permability using various membranes to mimic gastro-intestinal conditions, or the blood-brain or human skin barrier.