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Discovery

All drug development programs need efficient Discovery phases in order to screen potential candidates in timely and effective ways. Well-founded Discovery strikes a balance between eliminating those candidates where the profile makes development more challenging than it is worth, and others where the therapeutic possibilities and initial analyses are so promising that pre-formulation and formulation are indicated.

PhysChem AnalysisSolubilityExcipients

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pKa

We use aqueous or cosolvent approaches, and optimise the analysis conditions and perform repeat analyses until the best result is achieved.

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LogP and LogD

Pion’s gold standard pH-metric and shake-flask PhysChem assays yield the LogP and LogD of compounds.

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PAMPA

Pion’s PAMPA technology measures passive permability using various membranes to mimic gastro-intestinal conditions, or the blood-brain or human skin barrier.

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High Throughput Solubility

Aqueous solubility is one of the key physchem properties to identify in drug discovery. Unacceptable solubility is important to ascertain early on, before unsuitable compounds are taken any further into development.

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Gold and Platinum Standard Solubility

Work with Pion to get all the solubility test results you need to inform your discovery phase, and establish the profiles of candidates you’ll wish to develop further.

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Excipient Screening

Combining excipients with active compounds can improve their solubility, bioavailability and more. But which excipients will work best with your candidate compounds?.

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Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

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Scientific Instruments

Scientific Instruments

We provide novel in-vitro tools that promote quicker, more informed decision-making.

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Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

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