All drug development programs need efficient Discovery phases in order to screen potential candidates in timely and effective ways. Well-founded Discovery strikes a balance between eliminating those candidates where the profile makes development more challenging than it is worth, and others where the therapeutic possibilities and initial analyses are so promising that pre-formulation and formulation are indicated.
We use aqueous or cosolvent approaches, and optimise the analysis conditions and perform repeat analyses until the best result is achieved.
Pion’s gold standard pH-metric and shake-flask PhysChem assays yield the LogP and LogD of compounds.
Pion’s PAMPA technology measures passive permability using various membranes to mimic gastro-intestinal conditions, or the blood-brain or human skin barrier.
Aqueous solubility is one of the key physchem properties to identify in drug discovery. Unacceptable solubility is important to ascertain early on, before unsuitable compounds are taken any further into development.
Work with Pion to get all the solubility test results you need to inform your discovery phase, and establish the profiles of candidates you’ll wish to develop further.
Combining excipients with active compounds can improve their solubility, bioavailability and more. But which excipients will work best with your candidate compounds?.