sirius t3.svg

SiriusT3

Pion’s SiriusT3 is a fully automated instrument designed for compound screening and preparing detailed PhysChem profiles. It gives you accurate data using only sub milligram  sample quantities and can manage up to 80 pKa samples a day.

Add to quote basket

Overview

The SiriusT3 is an essential tool for analyzing pure single-element organic chemicals and their  salts. It measures pKa, logP, logD and solubility of ionizable drugs and small molecules, needing only very small amounts of sample. It is widely used in industrial and university labs, CROs and Pharma to support drug discovery research.

Customers describe the SiriusT3 as ‘integral’ for physchem compound characterization and ‘a pre-requisite for DMPK studies’. Others praise how it ‘integrates perfectly’ into analytical workflow and how it can ‘aid in [the] selection of compounds to move forward into further PK testing’.

Applications

The SiriusT3 can be used for a range of tasks across early stage physchem characterization and pre-formulation. These include:

  • Determine logP with built-in methods for high, medium and low logP
  • Understand the lipophilicity of a drug, how it varies with pH and its effect on absorption
  • Learning how the LogP changes due to solvent interactions, partitioning, precipitation or binding
  • Improving ADME predictions and evaluating how changes to the molecule can affect the logP for a desired application
  • Learning about a molecule’s capacity for supersaturation and LLPS formation
  • Determining intrinsic solubility, kinetic solubility and supersaturation

Features

Efficiency

The SiriusT3 makes measurements using only very small amounts of sample. Assays are performed in solution, 1 - 3 mL. Solutions are prepared in vials via automated dispensers and temperature-controlled between 12 - 70°C. You can weigh powdered samples directly into sample vials. Alterna-tively, you can prepare stock solutions of samples (e.g. 10 mM in DMSO) to pipette into vials. A built-in ultra-sonic bath helps to dissolve poorly soluble compounds. In addition, by running clean-up as-says, you can ensure that the SiriusT3 is always ‘ready to go’.

Accuracy

With the SiriusT3, you can determine logP at high, medium and low levels, using standard built-in methods for accurate, repeatable results.

Robotics

The SiriusT3 has a fully automated X and Y axis on [a?] titrator module, allowing you to run complicat-ed assays that would be challenging to set up manually.

Automation

The optional autoloader allows for convenience and high throughput by enabling you to run unat-tended experiments. You can run a sample sequence with both pKa and logP in the same run.

Optimization

With the SiriusT3, you have the option to integrate Assay Expert software from ACD Labs to optimize the design of experiments. This software allows you to analyze structure and identify ionizable groups, to indicate whether they are acidic or basic and to estimate pKa and logP values – all of which can inform your experiment design.

Simplicity

Many assays work with standard templates. Templates are supplied for all supported assays, including a logP method template. You can also save customized templates if required.

Speed

The Pion pH-metric method lets you determine logP and logD vs. pH and to study partition between water and octanol, toluene, dodecane and with other solvents. There are also built-in methods for high, medium and low logP. Sample requirement:  1 - 2 mg.

Resources

Acidity constants of hydroxyl groups placed in several flavonoids: Two flavanones, two flavones and five flavonols

Login

Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five”

Login

Advanced in vitro methods in generic drug product development

Login

"Utilizing Pion's SiriusT3 Platform" Webinar

Login

Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number

Login

SiriusT3 Product Brochure

Login

Extended Instrument Shut Down for Sirius T3 Storage Guidelines

Login

Diclofenac Prodrugs for Intra-articular Depot Injectables: In Vitro Hydrolysis and Species Variation

Login

Comparison of Cinchona Catalysts Containing Ethyl or Vinyl or Ethynyl Group at Their Quinuclidine Ring

Login

pKa and physchem property measurements for the pharmaceutical industry

Login

WEBINAR: How pKa Values are used in the Pharmaceutical Industry

Login

WEBINAR: Understanding and Measuring pKa

Login

LogP as a tool in intramolecular hydrogen bond considerations

Login

Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method

Login

Acid‐base titrations of proteins in small volumes

Login

The impact of cosolvent on measured log P values

Login

Determination of hydrogen bonding properties using logP

Login

Surface tension and supersaturation

Login

Measuring the isoelectric point of peptides by potentiometric titration

Login

Solubility Measurement

Login

Measuring Physiochemical Properties

Login

WEBINAR: Measuring solubility - what’s best for you?

Login

WEBINAR: Physicochemical Properties and their relation to ADMET

Login

WEBINAR: How Cheqsol Works

Login

WEBINAR: Investigating Supersaturation and Solubility Enhancement

Login

WEBINAR: State of the art UV methods for measuring pKa

Login

WEBINAR: Accessing hydrogen bond parameters and their application in drug discovery

Login

WEBINAR: Log P- History, Measurement and Applications in Drug Development

Login

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Login

Novel N-methylsulfonamide and Retro-N-methylsulfonamide Derivatives as 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors with Good ADME-Related Physicochemical Parameters

Login

Partial Protection Against Multiple RT-SHIV162P3 Vaginal Challenge of Rhesus Macaques by a Silicone Elastomer Vaginal Ring Releasing the NNRTI MC1220

Login

Physicochemical investigation of the influence of saccharide-based parenteral formulation excipients on l-p-boronphenylalanine solubilisation for boron neutron capture therapy

Login

Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists

Login

The ‘‘GI dissolution’’ method: a low volume, in vitro apparatus for assessing the dissolution/precipitation behaviour of an active pharmaceutical ingredient under biorelevant conditions

Login

Structural and thermodynamic analyses of alpha-L-fucosidase inhibitors

Login

New ideas about the solubility of drugs

Login

Assessment of distribution- pH profiles

Login

Multiwavelength spectrophotometric determination of acid dissociation constants Part VI. Deconvolution of binary mixtures of ionizable compounds

Login

Physicochemical characterization of sildenafil: Ionization, lipophilicity behaviour, and ionic-partition diagram studied by two-phase titration and electrochemistry

Login

Ionization Constants and Ionization profiles

Login

Measuring Physiochemical Properties 2

Login

4‐case chart to classify supersaturation and precipitation behavior

Login

Measuring pKa values in 2-propanol to gain process understanding

Login

Ionization Constants of Isoniazid and Benzimidazole

Login

pH-metric titration to characterize aci-nitro tautomerism

Login

Effects of solubility enhancing excipients

Login

Faster Dissolution Methods

Login

Low Volume Dissolution Assays

Login

The effect of dissolution media, torque and flow speed

Login

Biphasic dissolution studies of Felodipine

Login

Dissolution & precipitation studies of carbamazepine cocrystals with small scale assays

Login

Dissolution in presence of lipid to mimic absorption

Login

Dissolution Experiments in Lipid Layers

Login

Small scale assays for studying dissolution of cocrystals

Login

Small volume dissolution of a poorly soluble drug as solid dispersions

Login

Solubility of drugs in the presence of excipients in lipid based formulations

Login

Supersaturation & precipitation of ionizable drugs with cellulose polymers

Login

Physicochemical Studies of Triclosan

Login

Simulated Lung Fluid media

Login

Solubility measurement by extrapolation

Login

Solubilities of morphine analogs

Login

Characteristics of Felodipine ‐ HPMCAS Solid Dispersions

Login

Dissolution Performance of Inhaled Products in Simulated Lung Fluid

Login

In-situ Solubility Measurements of Ionizable Drugs

Login

Determination of Aqueous Solubility by Extrapolation

Login

A low volume method for screening Plasdone® polymers

Login

Assay Expert Flyer

Login

AN410 Measuring the isoelectric point pf peptides by potentiometric titration

Login

AN15 Determination of pKa Measurement or Prediction?

Login

AN14 Using NaOH and NaCL instead of KOM and KCI

Login

AN13 Measuring Solubility What’s Best for You?

Login

AN12 Introduction to logP and logD Measurement Using SiriusT3

Login

AN10 Measuring LogP of Samples that are Hard to Dissolve in Water and Octanol

Login

AN09 The Determination of Solubility - Pion CheqSol Explained

Login

AN08 Solubility and Supersaturation - A Brief Introduction

Login

AN07 the Pion GI Dissolution Assay

Login

AN06 The use of cosolvent pKa assays for poorly soluble compounds

Login

AN05 Measurement of extreme pKas

Login

AN04 Insights into BCS classification using Pion assays

Login

AN03 Blank Titrations Using the SiriusT3

Login

AN02 PKa measurements in 15 minutes - the SiriusT3 Fast UV pKa method

Login

AN01 High quality measurements for small sample amounts

Login

Pion SDi2 and Raman spectroscopy - study of diclofenac sodium salt

Login

Behavior of Basic Compounds in the Presence of Plasdone Polymers

Login

Determination of pKa values and Solubility pH Profiles of Selected ß blockers

Login

Supersaturation in additives and GI fluids

Login

Validation of titrimetric measurement of pKa, logP and solubility

Login

The intrinsic solubility of indomethacin

Login

Measuring the solubility of salts of basic drugs

Login

Potentiometric techniques for measuring solubility at 37°C

Login

Karl Box Sunrise Presentation

Login

Determination of Polymer Effectiveness

Login

Utilization of pH-Metric Titration

Login

Consumables

2.5mL Plunger

T306034

Add to quote basket

0.5mL Plunger

T306033

Add to quote basket

T3 - Three Capillary Assembly

T306036(3)

Add to quote basket

T3 - Five Capillary Assembly

T306036(5)

Add to quote basket

T3 - Six Capillary Assembly

T306036(6)

Add to quote basket

SiriusT3 - Mini-electrode

T485024

Add to quote basket

T3 - Sample Vials - Pack of 1000

T304036

Add to quote basket

T3 - Sample Vials - Pack of 100

T304037

Add to quote basket

T3 - Sample Vial Caps - Pack of 100

T304038

Add to quote basket

Wash Vial - Pack of 2

T304041

Add to quote basket

Buffer Vial - Pack of 5

T304042

Add to quote basket

T3 - Extended Life Deuterium Lamp

T409004

Add to quote basket

48 well vial rack

T210046

Add to quote basket

Stainless Steel Vial Rack

T210049

Add to quote basket

Ultrasonic Bath Cover

T210050

Add to quote basket

PEEK Electrode Block Rev G

T210045

Add to quote basket

Electrode Block Skirt

T210051

Add to quote basket

Waste Bottle

T305119

Add to quote basket

Wash Water Bottle

T305120

Add to quote basket

250mL Bottle

T305083

Add to quote basket

500mL Bottle

T305084

Add to quote basket

250mL Machined Bottle Top

T305086

Add to quote basket

250mL Bottle Top Plate (1 hole)

T305089

Add to quote basket

T3 - pH7 Buffer

1402002

Add to quote basket

T3 - Neutral Linear Buffer

T1404007

Add to quote basket

T3 - Electrode Filling Solution - Pack of 2

1402012

Add to quote basket

Mini Stirrer Assembly MKII

T1015066

Add to quote basket

Mini Bubbler

T210047

Add to quote basket
Analytical Services

Analytical Services

We can run your research for you.

Find out more

Products at a glance

Products at a glance

Check out the specifications and capabilities of Pion equipment.

Find out more

Analytical Services

Analytical Services

Our analysts run standard tests and assays for you on Pion equipment or serve as consultative partners.

Find out more

Resource Library

Resource Library

Latest citations of Pion instruments and services in industry white papers, webinars, videos, and case studies.

Find out more

Pion's quick response time to our service needs keeps downtime to a minimum in our lab.

QC Director
Tennessee

Close