Pion’s SiriusT3 is a fully automated instrument designed for compound screening and preparing detailed PhysChem profiles. It gives you accurate data using only sub milligram sample quantities and can manage up to 80 pKa samples a day.
The SiriusT3 is an essential tool for analyzing pure single-element organic chemicals and their salts. It measures pKa, logP, logD and solubility of ionizable drugs and small molecules, needing only very small amounts of sample. It is widely used in industrial and university labs, CROs and Pharma to support drug discovery research.
Customers describe the SiriusT3 as ‘integral’ for physchem compound characterization and ‘a pre-requisite for DMPK studies’. Others praise how it ‘integrates perfectly’ into analytical workflow and how it can ‘aid in [the] selection of compounds to move forward into further PK testing’.
The SiriusT3 can be used for a range of tasks across early stage physchem characterization and pre-formulation. These include:
The SiriusT3 makes measurements using only very small amounts of sample. Assays are performed in solution, 1 - 3 mL. Solutions are prepared in vials via automated dispensers and temperature-controlled between 12 - 70°C. You can weigh powdered samples directly into sample vials. Alterna-tively, you can prepare stock solutions of samples (e.g. 10 mM in DMSO) to pipette into vials. A built-in ultra-sonic bath helps to dissolve poorly soluble compounds. In addition, by running clean-up as-says, you can ensure that the SiriusT3 is always ‘ready to go’.
With the SiriusT3, you can determine logP at high, medium and low levels, using standard built-in methods for accurate, repeatable results.
The SiriusT3 has a fully automated X and Y axis on [a?] titrator module, allowing you to run complicat-ed assays that would be challenging to set up manually.
The optional autoloader allows for convenience and high throughput by enabling you to run unat-tended experiments. You can run a sample sequence with both pKa and logP in the same run.
With the SiriusT3, you have the option to integrate Assay Expert software from ACD Labs to optimize the design of experiments. This software allows you to analyze structure and identify ionizable groups, to indicate whether they are acidic or basic and to estimate pKa and logP values – all of which can inform your experiment design.
Many assays work with standard templates. Templates are supplied for all supported assays, including a logP method template. You can also save customized templates if required.
The Pion pH-metric method lets you determine logP and logD vs. pH and to study partition between water and octanol, toluene, dodecane and with other solvents. There are also built-in methods for high, medium and low logP. Sample requirement: 1 - 2 mg.
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pKa and physchem property measurements for the pharmaceutical industry
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AN15 Determination of pKa Measurement or Prediction?
AN14 Using NaOH and NaCL instead of KOM and KCI
AN13 Measuring Solubility What’s Best for You?
AN12 Introduction to logP and logD Measurement Using SiriusT3
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AN01 High quality measurements for small sample amounts
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